{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McLellan J"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)","NICHD NIH HHS","NIEHS NIH HHS","U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIMH NIH HHS","Nancy Lurie Marks Family Foundation (NLM Family Foundation)","NIGMS NIH HHS"],"pagination":["3018-3028"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12185337"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(7)"],"pubmed_abstract":["Maternal autoantibody-related autism (MARA) is a subtype of autism characterized by the maternal production of specific patterns of autoantibodies during pregnancy, which significantly increases the likelihood of an autism diagnosis in their children. Multiple patterns of MARA autoantibodies (MARA-ABS) have been identified, and differences in the severity of the autism phenotype associated with each autoantibody pattern have been described. In this study, we utilized preclinical rat models to further elucidate the differential effects of MARA-AB exposure based on the known clinical patterns, including the originally reported pattern of lactate dehydrogenase A and B (LDHA/B) + collapsin response mediator protein 1 (CRMP1) + stress-induced phosphoprotein 1 (STIP1), as well as the more recent"],"journal":["Molecular psychiatry"],"pubmed_title":["Gestational autoantibody exposure impacts early brain development in a rat model of MAR autism."],"pmcid":["PMC12185337"],"funding_grant_id":["P50 HD103526","P50 MH106438","P01 ES011269","R35 GM119831","P50HD103526","2P01ES011269-11","P50MH106438"],"pubmed_authors":["McLellan J","Van de Water J","Cichewicz K","Nord AS","Canales C","Corea M","Iosif AM","Rahbarian D","Bauman M"],"additional_accession":[]},"is_claimable":false,"name":"Gestational autoantibody exposure impacts early brain development in a rat model of MAR autism.","description":"Maternal autoantibody-related autism (MARA) is a subtype of autism characterized by the maternal production of specific patterns of autoantibodies during pregnancy, which significantly increases the likelihood of an autism diagnosis in their children. Multiple patterns of MARA autoantibodies (MARA-ABS) have been identified, and differences in the severity of the autism phenotype associated with each autoantibody pattern have been described. In this study, we utilized preclinical rat models to further elucidate the differential effects of MARA-AB exposure based on the known clinical patterns, including the originally reported pattern of lactate dehydrogenase A and B (LDHA/B) + collapsin response mediator protein 1 (CRMP1) + stress-induced phosphoprotein 1 (STIP1), as well as the more recent","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-06-01T15:55:09.561Z","creation":"2026-04-08T13:49:57.728Z"},"accession":"S-EPMC12185337","cross_references":{"pubmed":["39929953"],"doi":["10.1038/s41380-025-02907-3"]}}