{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(7)"],"submitter":["van Gennip LLA"],"pubmed_abstract":["<h4>Purpose</h4>To evaluate periodontal health after allogeneic haematopoietic cell transplantation (HCT), and its association with conditioning regimen intensity.<h4>Methods</h4>This single-centre retrospective cohort study included 82 allogeneic HCT recipients between 01/08/2017 and 31/03/2022. Probing pocket depth (PPD), bleeding on probing (BOP), periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) were assessed pre- and post-HCT. Change scores were calculated, and regression models were applied to analyse associations with conditioning intensity. Conditioning regimens were categorised based on intensity as non-myeloablative (NMA), reduced intensity (RIC) or myeloablative (MA).<h4>Results</h4>HCT recipients had a median age of 59 years (IQR 48-66); 63% were male. Median time to HCT was 53 days (IQR 29-89), median follow-up was 279 days (IQR 183-349). Severe periodontitis (≥ 1 site with PPD ≥ 6 mm) was observed in 37% of patients pre-HCT and 20% of patients post-HCT. PPD, BOP, PESA and PISA decreased from pre- to post-HCT, by 0.26 mm [95%CI 0.16;0.37], 8% [95%CI 5;12], 140 mm<sup>2</sup> [95%CI 89;190] and 123 mm<sup>2</sup> [95%CI 83;185], respectively. Prevalence of severe periodontitis decreased from pre- to post-HCT in all groups: NMA 50% to 27%, RIC 32% to 19%, MA 31% to 13%. Conditioning intensity was statistically significantly associated with post-HCT PPD and PESA; however, differences were small. No statistically significant differences were observed in post-HCT PISA between conditioning regimens.<h4>Conclusion</h4>Periodontal health improved marginally in the short-term following HCT and supportive oral care. Differences in post-HCT periodontal health between patients conditioned with NMA, RIC, and MA were not clinically relevant."],"journal":["Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer"],"pagination":["612"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12185657"],"repository":["biostudies-literature"],"pubmed_title":["Periodontal changes after haematopoietic cell transplantation and the role of conditioning regimen intensity."],"pmcid":["PMC12185657"],"pubmed_authors":["van Leeuwen SJM","Blijlevens NMA","Huysmans MDNJM","Hannink G","Thomas RZ","van Gennip LLA","Bulthuis MS","Bronkhorst EM"],"additional_accession":[]},"is_claimable":false,"name":"Periodontal changes after haematopoietic cell transplantation and the role of conditioning regimen intensity.","description":"<h4>Purpose</h4>To evaluate periodontal health after allogeneic haematopoietic cell transplantation (HCT), and its association with conditioning regimen intensity.<h4>Methods</h4>This single-centre retrospective cohort study included 82 allogeneic HCT recipients between 01/08/2017 and 31/03/2022. Probing pocket depth (PPD), bleeding on probing (BOP), periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) were assessed pre- and post-HCT. Change scores were calculated, and regression models were applied to analyse associations with conditioning intensity. Conditioning regimens were categorised based on intensity as non-myeloablative (NMA), reduced intensity (RIC) or myeloablative (MA).<h4>Results</h4>HCT recipients had a median age of 59 years (IQR 48-66); 63% were male. Median time to HCT was 53 days (IQR 29-89), median follow-up was 279 days (IQR 183-349). Severe periodontitis (≥ 1 site with PPD ≥ 6 mm) was observed in 37% of patients pre-HCT and 20% of patients post-HCT. PPD, BOP, PESA and PISA decreased from pre- to post-HCT, by 0.26 mm [95%CI 0.16;0.37], 8% [95%CI 5;12], 140 mm<sup>2</sup> [95%CI 89;190] and 123 mm<sup>2</sup> [95%CI 83;185], respectively. Prevalence of severe periodontitis decreased from pre- to post-HCT in all groups: NMA 50% to 27%, RIC 32% to 19%, MA 31% to 13%. Conditioning intensity was statistically significantly associated with post-HCT PPD and PESA; however, differences were small. No statistically significant differences were observed in post-HCT PISA between conditioning regimens.<h4>Conclusion</h4>Periodontal health improved marginally in the short-term following HCT and supportive oral care. Differences in post-HCT periodontal health between patients conditioned with NMA, RIC, and MA were not clinically relevant.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-03T07:11:20.441Z","creation":"2025-08-16T03:06:45.923Z"},"accession":"S-EPMC12185657","cross_references":{"pubmed":["40548989"],"doi":["10.1007/s00520-025-09654-9"]}}