biostudies-literatureUnknown33(7)van Gennip LLA<h4>Purpose</h4>To evaluate periodontal health after allogeneic haematopoietic cell transplantation (HCT), and its association with conditioning regimen intensity.<h4>Methods</h4>This single-centre retrospective cohort study included 82 allogeneic HCT recipients between 01/08/2017 and 31/03/2022. Probing pocket depth (PPD), bleeding on probing (BOP), periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) were assessed pre- and post-HCT. Change scores were calculated, and regression models were applied to analyse associations with conditioning intensity. Conditioning regimens were categorised based on intensity as non-myeloablative (NMA), reduced intensity (RIC) or myeloablative (MA).<h4>Results</h4>HCT recipients had a median age of 59 years (IQR 48-66); 63% were male. Median time to HCT was 53 days (IQR 29-89), median follow-up was 279 days (IQR 183-349). Severe periodontitis (≥ 1 site with PPD ≥ 6 mm) was observed in 37% of patients pre-HCT and 20% of patients post-HCT. PPD, BOP, PESA and PISA decreased from pre- to post-HCT, by 0.26 mm [95%CI 0.16;0.37], 8% [95%CI 5;12], 140 mm² [95%CI 89;190] and 123 mm² [95%CI 83;185], respectively. Prevalence of severe periodontitis decreased from pre- to post-HCT in all groups: NMA 50% to 27%, RIC 32% to 19%, MA 31% to 13%. Conditioning intensity was statistically significantly associated with post-HCT PPD and PESA; however, differences were small. No statistically significant differences were observed in post-HCT PISA between conditioning regimens.<h4>Conclusion</h4>Periodontal health improved marginally in the short-term following HCT and supportive oral care. Differences in post-HCT periodontal health between patients conditioned with NMA, RIC, and MA were not clinically relevant.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer612https://www.ebi.ac.uk/biostudies/studies/S-EPMC12185657biostudies-literaturePeriodontal changes after haematopoietic cell transplantation and the role of conditioning regimen intensity.PMC12185657van Leeuwen SJMBlijlevens NMAHuysmans MDNJMHannink GThomas RZvan Gennip LLABulthuis MSBronkhorst EMfalsePeriodontal changes after haematopoietic cell transplantation and the role of conditioning regimen intensity.<h4>Purpose</h4>To evaluate periodontal health after allogeneic haematopoietic cell transplantation (HCT), and its association with conditioning regimen intensity.<h4>Methods</h4>This single-centre retrospective cohort study included 82 allogeneic HCT recipients between 01/08/2017 and 31/03/2022. Probing pocket depth (PPD), bleeding on probing (BOP), periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) were assessed pre- and post-HCT. Change scores were calculated, and regression models were applied to analyse associations with conditioning intensity. Conditioning regimens were categorised based on intensity as non-myeloablative (NMA), reduced intensity (RIC) or myeloablative (MA).<h4>Results</h4>HCT recipients had a median age of 59 years (IQR 48-66); 63% were male. Median time to HCT was 53 days (IQR 29-89), median follow-up was 279 days (IQR 183-349). Severe periodontitis (≥ 1 site with PPD ≥ 6 mm) was observed in 37% of patients pre-HCT and 20% of patients post-HCT. PPD, BOP, PESA and PISA decreased from pre- to post-HCT, by 0.26 mm [95%CI 0.16;0.37], 8% [95%CI 5;12], 140 mm² [95%CI 89;190] and 123 mm² [95%CI 83;185], respectively. Prevalence of severe periodontitis decreased from pre- to post-HCT in all groups: NMA 50% to 27%, RIC 32% to 19%, MA 31% to 13%. Conditioning intensity was statistically significantly associated with post-HCT PPD and PESA; however, differences were small. No statistically significant differences were observed in post-HCT PISA between conditioning regimens.<h4>Conclusion</h4>Periodontal health improved marginally in the short-term following HCT and supportive oral care. Differences in post-HCT periodontal health between patients conditioned with NMA, RIC, and MA were not clinically relevant.2025-01-01T00:00:00Z2025 Jun2026-06-03T07:11:20.441Z2025-08-16T03:06:45.923ZS-EPMC121856574054898910.1007/s00520-025-09654-9