biostudies-literatureUnknownLiu JNIBIB NIH HHSNCRR NIH HHSNINDS NIH HHS<h4>Purpose</h4>To demonstrate the feasibility and performance of mesoscopic whole brain T₂*-weighted (T₂*w) MRI at 10.5 T by combining a motion-robust multi-echo gradient-echo (GRE) method with high-density RF receive arrays.<h4>Methods</h4>Multi-echo GRE data were collected in healthy adults at isotropic 0.5 mm resolution using a custom-built 16-channel transmit/80-channel receive (16Tx/80Rx) RF coil. Whole brain images were reconstructed with navigator-guided joint motion and field correction and were used for quantitative <i>R</i> ₂* and susceptibility (<i>χ</i>) mapping. Intrinsic signal-to-noise ratio (iSNR) and quantification precision for <i>R</i> ₂* and <i>χ</i> were also estimated. The results were compared with those obtained in the sabioRxiv : the preprint server for biology2025.04.21.649819https://www.ebi.ac.uk/biostudies/studies/S-EPMC12190817biostudies-literatureMesoscopic whole-brain T&lt;sub&gt;2&lt;/sub&gt;*-weighted and associated quantitative MRI in healthy humans at 10.5 T.PMC12190817R01 NS136490P41 EB027061S10 RR029672U01 EB025144Waks MLiu JAuerbach EEryaman YLagore RUgurbil KAdriany GGrant ADuyn JHDelabarre LHuang YSadeghi-Tarakameh Avan Gelderen Pde Zwart JAWu XfalseMesoscopic whole-brain T&lt;sub&gt;2&lt;/sub&gt;*-weighted and associated quantitative MRI in healthy humans at 10.5 T.<h4>Purpose</h4>To demonstrate the feasibility and performance of mesoscopic whole brain T₂*-weighted (T₂*w) MRI at 10.5 T by combining a motion-robust multi-echo gradient-echo (GRE) method with high-density RF receive arrays.<h4>Methods</h4>Multi-echo GRE data were collected in healthy adults at isotropic 0.5 mm resolution using a custom-built 16-channel transmit/80-channel receive (16Tx/80Rx) RF coil. Whole brain images were reconstructed with navigator-guided joint motion and field correction and were used for quantitative <i>R</i> ₂* and susceptibility (<i>χ</i>) mapping. Intrinsic signal-to-noise ratio (iSNR) and quantification precision for <i>R</i> ₂* and <i>χ</i> were also estimated. The results were compared with those obtained in the sa2025-01-01T00:00:00Z2025 Apr2026-04-08T16:12:25.21Z2026-04-08T06:11:04.806ZS-EPMC121908174056806410.1101/2025.04.21.649819