biostudies-literatureLloret Torres MENational Institute on Alcohol Abuse and AlcoholismU.S. Department of DefenseImaging Core at the Institute of Neurobiology National Science FoundationNational Institute on Minority Health and Health DisparitiesNIGMS NIH HHSe0322576https://www.ebi.ac.uk/biostudies/studies/S-EPMC12193044biostudies-literatureUnknown20(6)<h4>Introduction</h4>Stressor-related disorders frequently co-occur with alcohol use disorder (AUD). This necessitates an understanding of the physiological and genetic factors contributing to this relationship. Binge drinking is the most common method of alcohol consumption among adolescent males and significantly increases the risk of developing comorbid stressor-related disorders and AUD. In experiments modeling the effects of a single binge-like alcohol exposure in male adolescent mice, we observed a clear deficit in context extinction learning. This exposure led to a significant initial increase in subsequent voluntary drinking on day one, as measured by the every-other-day (EOD) two-bottle choice drinking assay, which normalized thereafter.<h4>Methods</h4>For this study we performed PloS oneComparative mRNA profile analysis from NAc of adolescent male mice after binge-like alcohol exposure eliciting deficits in context fear extinction learning.PMC12193044U54 MD007600G12MD 007600P20 GM10364252680-LS-ISP30 GM1493671R01AA027808DBI-0115825Lay Rivera XXRuiz Bolivar DFRoche-Lima APena Seneriz YLFlorian Alsina JADieppa Rodriguez MCardona Jordan KLloret Torres METosado Rodriguez ELColon Rivera PAGarcia Colon JOGonzalez Del Toro JVelazquez-Marrero CCapella Muniz JLRivas Jimenez AfalseComparative mRNA profile analysis from NAc of adolescent male mice after binge-like alcohol exposure eliciting deficits in context fear extinction learning.<h4>Introduction</h4>Stressor-related disorders frequently co-occur with alcohol use disorder (AUD). This necessitates an understanding of the physiological and genetic factors contributing to this relationship. Binge drinking is the most common method of alcohol consumption among adolescent males and significantly increases the risk of developing comorbid stressor-related disorders and AUD. In experiments modeling the effects of a single binge-like alcohol exposure in male adolescent mice, we observed a clear deficit in context extinction learning. This exposure led to a significant initial increase in subsequent voluntary drinking on day one, as measured by the every-other-day (EOD) two-bottle choice drinking assay, which normalized thereafter.<h4>Methods</h4>For this study we performed 2025-01-01T00:00:00Z20252026-04-25T03:30:18.636Z2026-04-25T03:22:46.882ZS-EPMC121930444056084210.1371/journal.pone.0322576