{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang L"],"funding":["National Natural Science Foundation of China for Young Scientists","Special Fund of Guangxi University of Chinese Medicine","Innovation Project of Guangxi Graduate Education of GXUCM"],"pagination":["824"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12196505"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(6)"],"pubmed_abstract":["<b>Background/Objectives:</b><i>Camellia nitidissima</i> Chi (<i>C. nitidissima</i>), a traditional Chinese \"food and medicine homology\" plant, has demonstrated potential anti-tumor properties. However, its mechanisms of anti-lung cancer activity via ferroptosis remain unclear. This study aimed to construct an integrated research system of \"natural product extraction-purification, bioactivity evaluation, and computational drug screening\" to explore the bioactive compounds in <i>C. nitidissima</i> leaves targeting HMOX-1-mediated ferroptosis and their anti-lung cancer mechanisms. <b>Methods:</b> Active fractions were prepared using ethanol extraction combined with polyamide column chromatography. The anti-lung cancer activity was evaluated using the NCI-H1975 cell model. Ferroptosis was ver"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["Identification of HMOX-1-Targeting Natural Compounds in &lt;i&gt;Camellia nitidissima&lt;/i&gt; Chi for NSCLC Therapy: Integrating Bioassay and In Silico Screening Approaches."],"pmcid":["PMC12196505"],"funding_grant_id":["82204756","YCSY2023056","2025GXNSFAA069904"],"pubmed_authors":["Liang C","Zhang F","Liang H","Xie J","Qin X","Deng J","Zhang L","Du Z","Hou X","Zhong M","Mo Y","Hao E"],"additional_accession":[]},"is_claimable":false,"name":"Identification of HMOX-1-Targeting Natural Compounds in &lt;i&gt;Camellia nitidissima&lt;/i&gt; Chi for NSCLC Therapy: Integrating Bioassay and In Silico Screening Approaches.","description":"<b>Background/Objectives:</b><i>Camellia nitidissima</i> Chi (<i>C. nitidissima</i>), a traditional Chinese \"food and medicine homology\" plant, has demonstrated potential anti-tumor properties. However, its mechanisms of anti-lung cancer activity via ferroptosis remain unclear. This study aimed to construct an integrated research system of \"natural product extraction-purification, bioactivity evaluation, and computational drug screening\" to explore the bioactive compounds in <i>C. nitidissima</i> leaves targeting HMOX-1-mediated ferroptosis and their anti-lung cancer mechanisms. <b>Methods:</b> Active fractions were prepared using ethanol extraction combined with polyamide column chromatography. The anti-lung cancer activity was evaluated using the NCI-H1975 cell model. Ferroptosis was ver","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-04-15T03:20:43.784Z","creation":"2026-04-15T03:09:54.923Z"},"accession":"S-EPMC12196505","cross_references":{"pubmed":["40573219"],"doi":["10.3390/ph18060824"]}}