biostudies-literatureMaduka CVNIAMS NIH HHS1308-1321https://www.ebi.ac.uk/biostudies/studies/S-EPMC12197073biostudies-literatureUnknown8(10)Circulating monocytes infiltrate and coordinate immune responses in tissues surrounding implanted biomaterials and in other inflamed tissues. Here we show that immunometabolic cues in the biomaterial microenvironment govern the trafficking of immune cells, including neutrophils and monocytes, in a manner dependent on the chemokine receptor 2 (CCR2) and the C-X3-C motif chemokine receptor 1 (CX3CR1). This affects the composition and activation states of macrophage and dendritic cell populations, ultimately orchestrating the relative composition of pro-inflammatory, transitory and anti-inflammatory CCR2⁺, CX3CR1⁺ and CCR2⁺ CX3CR1⁺ immune cell populations. In amorphous polylactide implants, modifying immunometabolism by glycolytic inhibition drives Nature biomedical engineeringImmunometabolic cues recompose and reprogram the microenvironment around implanted biomaterials.PMC12197073R01 AR083086Elisseeff JHKiselev AStauff JMakela AVPope HWinton WPHabeeb OMUral EPark SKuhnert MMSchmitter-Sanchez ADDonneys AScott PJHHankenson KDAlhaj MMaduka CVTundo AOlive AJNarayan RChen SContag CHStivers KBfalseImmunometabolic cues recompose and reprogram the microenvironment around implanted biomaterials.Circulating monocytes infiltrate and coordinate immune responses in tissues surrounding implanted biomaterials and in other inflamed tissues. Here we show that immunometabolic cues in the biomaterial microenvironment govern the trafficking of immune cells, including neutrophils and monocytes, in a manner dependent on the chemokine receptor 2 (CCR2) and the C-X3-C motif chemokine receptor 1 (CX3CR1). This affects the composition and activation states of macrophage and dendritic cell populations, ultimately orchestrating the relative composition of pro-inflammatory, transitory and anti-inflammatory CCR2⁺, CX3CR1⁺ and CCR2⁺ CX3CR1⁺ immune cell populations. In amorphous polylactide implants, modifying immunometabolism by glycolytic inhibition drives 2024-01-01T00:00:00Z2024 Oct2026-06-11T05:16:49.231Z2026-06-11T03:07:54.496ZS-EPMC121970733936726410.1038/s41551-024-01260-0