{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang B"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","Cure Alzheimer's Fund (Alzheimer's Disease Research Foundation)","NIA NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Aging","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","NINDS NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)","Cure Alzheimer’s Fund"],"pagination":["48-62"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12203451"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(1)"],"pubmed_abstract":["Transcription factor EB (TFEB) mediates gene expression through binding to the coordinated lysosome expression and regulation (CLEAR) sequence. TFEB targets include subunits of the vacuolar ATPase (v-ATPase), which are essential for lysosome acidification. Single-nucleus RNA sequencing of wild-type and PS19 (Tau) transgenic mice expressing the P301S mutant tau identified three unique microglia subclusters in Tau mice that were associated with heightened lysosome and immune pathway genes. To explore the lysosome-immune relationship, we specifically disrupted the TFEB-v-ATPase signaling by creating a knock-in mouse line in which the CLEAR sequence of one of the v-ATPase subunits, Atp6v1h, was mutated. CLEAR mutant exhibited a muted response to TFEB, resulting in impaired lysosomal acidificat"],"journal":["Nature neuroscience"],"pubmed_title":["TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy."],"pmcid":["PMC12203451"],"funding_grant_id":["RF1 NS093652","AG020670","AG062257","P01 AG066606","NA","AG066606","RF1 AG020670","NS093652","R00 AG062746","AG062746","RF1 AG062257"],"pubmed_authors":["Li H","Martini-Stoica H","Lu TC","Zheng H","Wang B","Sardiello M","Wang S","Qi Y","Qi C","Xiong W","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy.","description":"Transcription factor EB (TFEB) mediates gene expression through binding to the coordinated lysosome expression and regulation (CLEAR) sequence. TFEB targets include subunits of the vacuolar ATPase (v-ATPase), which are essential for lysosome acidification. Single-nucleus RNA sequencing of wild-type and PS19 (Tau) transgenic mice expressing the P301S mutant tau identified three unique microglia subclusters in Tau mice that were associated with heightened lysosome and immune pathway genes. To explore the lysosome-immune relationship, we specifically disrupted the TFEB-v-ATPase signaling by creating a knock-in mouse line in which the CLEAR sequence of one of the v-ATPase subunits, Atp6v1h, was mutated. CLEAR mutant exhibited a muted response to TFEB, resulting in impaired lysosomal acidificat","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-06-01T15:29:07.564Z","creation":"2026-04-08T13:42:48.14Z"},"accession":"S-EPMC12203451","cross_references":{"pubmed":["37985800"],"doi":["10.1038/s41593-023-01494-2"]}}