{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Riner AN"],"funding":["NHGRI NIH HHS","NCI NIH HHS"],"pagination":["e171-e178"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12203564"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54(3)"],"pubmed_abstract":["<h4>Objectives</h4>Black/African American (B/AA) pancreatic ductal adenocarcinoma (PDAC) patients have worse clinical outcomes than White patients and are underrepresented in genomic databases. We aimed to expand our understanding of the PDAC somatic landscape from a diverse cohort.<h4>Materials and methods</h4>Formalin-fixed paraffin-embedded specimens from 24 surgically resected PDAC cases were collected, with self-reported race/ethnicity. Whole exome sequencing was performed on malignant and benign tissue. Bioinformatics analysis included deduction of genetic ancestry and somatic mutational analysis, with comparisons to public datasets.<h4>Results</h4>Out of 24 cases, 17 identified as B/AA race; genetic ancestry analysis confirmed proportions of Sub-Saharan African ancestry greater than"],"journal":["Pancreas"],"pubmed_title":["Somatic Genomic Profiling of Pancreatic Ductal Adenocarcinomas From a Diverse Cohort of Patients."],"pmcid":["PMC12203564"],"funding_grant_id":["U54 CA233465","R01 CA242003","U54 CA233396","P30 CA014089","P30 CA247796","T32 HG008958","U54 CA233444"],"pubmed_authors":["Qian J","Carpten JD","Herremans KM","Reams R","Akki A","Velazquez-Villarreal EI","Loza D","Jin Y","Riner AN","George TJ","Stern MC","Redda K","Chamala S","Craig DW","Agyare E","Rajpara S","Wilkie DJ","Han B","Odedina FT","Trevino JG","Williams TM","Raj R","Hughes SJ","Merchant N"],"additional_accession":[]},"is_claimable":false,"name":"Somatic Genomic Profiling of Pancreatic Ductal Adenocarcinomas From a Diverse Cohort of Patients.","description":"<h4>Objectives</h4>Black/African American (B/AA) pancreatic ductal adenocarcinoma (PDAC) patients have worse clinical outcomes than White patients and are underrepresented in genomic databases. We aimed to expand our understanding of the PDAC somatic landscape from a diverse cohort.<h4>Materials and methods</h4>Formalin-fixed paraffin-embedded specimens from 24 surgically resected PDAC cases were collected, with self-reported race/ethnicity. Whole exome sequencing was performed on malignant and benign tissue. Bioinformatics analysis included deduction of genetic ancestry and somatic mutational analysis, with comparisons to public datasets.<h4>Results</h4>Out of 24 cases, 17 identified as B/AA race; genetic ancestry analysis confirmed proportions of Sub-Saharan African ancestry greater than","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-07-16T23:36:45.565Z","creation":"2026-07-12T03:11:30.528Z"},"accession":"S-EPMC12203564","cross_references":{"pubmed":["39999309"],"doi":["10.1097/mpa.0000000000002408","10.1097/MPA.0000000000002408"]}}