biostudies-literatureRiner ANNHGRI NIH HHSNCI NIH HHSe171-e178https://www.ebi.ac.uk/biostudies/studies/S-EPMC12203564biostudies-literatureUnknown54(3)<h4>Objectives</h4>Black/African American (B/AA) pancreatic ductal adenocarcinoma (PDAC) patients have worse clinical outcomes than White patients and are underrepresented in genomic databases. We aimed to expand our understanding of the PDAC somatic landscape from a diverse cohort.<h4>Materials and methods</h4>Formalin-fixed paraffin-embedded specimens from 24 surgically resected PDAC cases were collected, with self-reported race/ethnicity. Whole exome sequencing was performed on malignant and benign tissue. Bioinformatics analysis included deduction of genetic ancestry and somatic mutational analysis, with comparisons to public datasets.<h4>Results</h4>Out of 24 cases, 17 identified as B/AA race; genetic ancestry analysis confirmed proportions of Sub-Saharan African ancestry greater thanPancreasSomatic Genomic Profiling of Pancreatic Ductal Adenocarcinomas From a Diverse Cohort of Patients.PMC12203564U54 CA233465R01 CA242003U54 CA233396P30 CA014089P30 CA247796T32 HG008958U54 CA233444Qian JCarpten JDHerremans KMReams RAkki AVelazquez-Villarreal EILoza DJin YRiner ANGeorge TJStern MCRedda KChamala SCraig DWAgyare ERajpara SWilkie DJHan BOdedina FTTrevino JGWilliams TMRaj RHughes SJMerchant NfalseSomatic Genomic Profiling of Pancreatic Ductal Adenocarcinomas From a Diverse Cohort of Patients.<h4>Objectives</h4>Black/African American (B/AA) pancreatic ductal adenocarcinoma (PDAC) patients have worse clinical outcomes than White patients and are underrepresented in genomic databases. We aimed to expand our understanding of the PDAC somatic landscape from a diverse cohort.<h4>Materials and methods</h4>Formalin-fixed paraffin-embedded specimens from 24 surgically resected PDAC cases were collected, with self-reported race/ethnicity. Whole exome sequencing was performed on malignant and benign tissue. Bioinformatics analysis included deduction of genetic ancestry and somatic mutational analysis, with comparisons to public datasets.<h4>Results</h4>Out of 24 cases, 17 identified as B/AA race; genetic ancestry analysis confirmed proportions of Sub-Saharan African ancestry greater than2025-01-01T00:00:00Z2025 Mar2026-07-16T23:36:45.565Z2026-07-12T03:11:30.528ZS-EPMC122035643999930910.1097/mpa.000000000000240810.1097/MPA.0000000000002408