{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(6)"],"submitter":["Wang C"],"funding":["Shanghai Municipal Health Commission","National Science Fund for Distinguished Young Scholars","National Natural Science Foundation of China","National Postdoctoral Program for Innovative Talents"],"pubmed_abstract":["Resective surgery is an effective approach for long-term seizure control in drug-resistant focal epilepsy when the epileptic focus (EF) can be accurately delineated and removed. However, intraoperative mapping of EF with electrocorticography is laborious, time-consuming, and highly vulnerable to the effects of anesthesia. Here, we demonstrated that activated microglia can be reliable biomarkers for EF localization. Leveraging a newly developed ratiometric Raman nanosensor, ultraHOCls, we successfully visualize proinflammatory microglia in live epileptic mice, allowing for precise EF delineation without the interference of anesthesia. Compared to electrocorticography-guided surgery, ultraHOCl-guided surgery results in a substantial 61% reduction in total seizure burden in epileptic mouse mo"],"journal":["Cell reports. Medicine"],"pagination":["102155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12208331"],"repository":["biostudies-literature"],"pubmed_title":["Ultrabright ratiometric Raman-guided epilepsy surgery by intraoperatively visualizing proinflammatory microglia."],"pmcid":["PMC12208331"],"pubmed_authors":["Zhang J","Wang C","Wang D","Wang J","Wang L","Jiang Y","Ding Y","Xie F","Zheng H","Wang Q","Chen Y","Zhao J","Zheng F","Mao Y","Yan K","Li C","Fan Z","Chen M","Chen L","Xiao X","Sun W","Zhou X","Guan Y","Li Z","Lei Z","Hu J","Cai Z","Zhu X","Duan W"],"additional_accession":[]},"is_claimable":false,"name":"Ultrabright ratiometric Raman-guided epilepsy surgery by intraoperatively visualizing proinflammatory microglia.","description":"Resective surgery is an effective approach for long-term seizure control in drug-resistant focal epilepsy when the epileptic focus (EF) can be accurately delineated and removed. However, intraoperative mapping of EF with electrocorticography is laborious, time-consuming, and highly vulnerable to the effects of anesthesia. Here, we demonstrated that activated microglia can be reliable biomarkers for EF localization. Leveraging a newly developed ratiometric Raman nanosensor, ultraHOCls, we successfully visualize proinflammatory microglia in live epileptic mice, allowing for precise EF delineation without the interference of anesthesia. Compared to electrocorticography-guided surgery, ultraHOCl-guided surgery results in a substantial 61% reduction in total seizure burden in epileptic mouse mo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-01T16:01:47.528Z","creation":"2026-04-08T14:04:23.756Z"},"accession":"S-EPMC12208331","cross_references":{"pubmed":["40449482"],"doi":["10.1016/j.xcrm.2025.102155"]}}