{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(7)"],"submitter":["Chang R"],"pubmed_abstract":["Abdominal aortic aneurysm (AAA) is a serious cardiovascular disease associated with chronic inflammation. The purpose of this study was to use the Olink proteomics to reveal serum inflammatory markers in AAA. We examined the expression levels of 92 inflammation-related proteins in patients with AAA (<i>n</i> = 18) and healthy individuals (<i>n</i> = 10) using the Olink proximity extension assay (PEA) inflammatory plate. Olink proteomics identified 38 differential proteins. Combined analysis of Olink proteomics and GSE183464 showed interleukin-6 (IL-6) and tumor necrosis factor receptor superfamily member 9 (TNFRSF9) were upregulated at both gene and protein levels in AAA patients. The ELISA results were consistent with the Olink proteomics results, and the receiver operating characteristic"],"journal":["iScience"],"pagination":["112828"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12209979"],"repository":["biostudies-literature"],"pubmed_title":["Olink proteomics reveals TNFRSF9 as a biomarker for abdominal aortic aneurysms."],"pmcid":["PMC12209979"],"pubmed_authors":["Li Y","Chang R","Chen J","Dong H","Fan K","Lu C","Wang H","Li L","Zhang R","Qiao M","Gao S"],"additional_accession":[]},"is_claimable":false,"name":"Olink proteomics reveals TNFRSF9 as a biomarker for abdominal aortic aneurysms.","description":"Abdominal aortic aneurysm (AAA) is a serious cardiovascular disease associated with chronic inflammation. The purpose of this study was to use the Olink proteomics to reveal serum inflammatory markers in AAA. We examined the expression levels of 92 inflammation-related proteins in patients with AAA (<i>n</i> = 18) and healthy individuals (<i>n</i> = 10) using the Olink proximity extension assay (PEA) inflammatory plate. Olink proteomics identified 38 differential proteins. Combined analysis of Olink proteomics and GSE183464 showed interleukin-6 (IL-6) and tumor necrosis factor receptor superfamily member 9 (TNFRSF9) were upregulated at both gene and protein levels in AAA patients. The ELISA results were consistent with the Olink proteomics results, and the receiver operating characteristic","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-26T11:00:52.209Z","creation":"2026-05-24T03:07:12.759Z"},"accession":"S-EPMC12209979","cross_references":{"pubmed":["40599317"],"doi":["10.1016/j.isci.2025.112828"]}}