{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim IV"],"funding":["European Research Council"],"pagination":["1097-1105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12221973"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["642(8069)"],"pubmed_abstract":["In bilaterian animals, gene regulation is shaped by a combination of linear and spatial regulatory information. Regulatory elements along the genome are integrated into gene regulatory landscapes through chromatin compartmentalization<sup>1,2</sup>, insulation of neighbouring genomic regions<sup>3,4</sup> and chromatin looping that brings together distal cis-regulatory sequences<sup>5</sup>. However, the evolution of these regulatory features is unknown because the three-dimensional genome architecture of most animal lineages remains unexplored<sup>6,7</sup>. To trace the evolutionary origins of animal genome regulation, here we characterized the physical organization of the genome in non-bilaterian animals (sponges, ctenophores, placozoans and cnidarians)<sup>8,9</sup> and their closest u"],"journal":["Nature"],"pubmed_title":["Chromatin loops are an ancestral hallmark of the animal regulatory genome."],"pmcid":["PMC12221973"],"funding_grant_id":["851647","950230"],"pubmed_authors":["Bykov NS","Marti-Renom MA","Grau-Bove X","Suga H","Navarrete C","Zolotarov G","Canas-Armenteros D","de Mendoza A","Kim IV","Iglesias M","Burkhardt P","Elek A","Sebe-Pedros A","Soto-Angel JJ","Ksiezopolska E","Montgomery SA","Leys SP"],"additional_accession":[]},"is_claimable":false,"name":"Chromatin loops are an ancestral hallmark of the animal regulatory genome.","description":"In bilaterian animals, gene regulation is shaped by a combination of linear and spatial regulatory information. Regulatory elements along the genome are integrated into gene regulatory landscapes through chromatin compartmentalization<sup>1,2</sup>, insulation of neighbouring genomic regions<sup>3,4</sup> and chromatin looping that brings together distal cis-regulatory sequences<sup>5</sup>. However, the evolution of these regulatory features is unknown because the three-dimensional genome architecture of most animal lineages remains unexplored<sup>6,7</sup>. To trace the evolutionary origins of animal genome regulation, here we characterized the physical organization of the genome in non-bilaterian animals (sponges, ctenophores, placozoans and cnidarians)<sup>8,9</sup> and their closest u","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-03T05:51:39.488Z","creation":"2026-04-25T03:15:43.093Z"},"accession":"S-EPMC12221973","cross_references":{"pubmed":["40335694"],"doi":["10.1038/s41586-025-08960-w"]}}