{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dheedene W"],"funding":["Cosmetics Europe/European Commission FP7 Grant","European Research Council","KU Leuven (Katholieke Universiteit Leuven)","EC | EC Seventh Framework Programm | FP7 People: Marie-Curie Actions (FP7-PEOPLE - Specific Programme \"People\" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))","EC | EU Framework Programme for Research and Innovation H2020 | H2020 Excellent Science (H2020 Priority Excellent Science)","Erasmus University Rotterdam | Erasmus Universitair Medisch Centrum Rotterdam (Erasmus Universitair Medisch Centrum)","ZonMw","Interuniversity Attraction Poles Grant","Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)"],"pagination":["23434"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12222841"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, features liver sinusoidal endothelial cell (LSEC) alterations with ill-defined driving factors. Zinc-Finger E-Box-binding Homeobox (ZEB)2 in LSECs preserves their specialized features, prevents capillarization and protects against liver fibrosis. To investigate a potential protective role against steatosis, the initial MASLD stage, we fed EC-specific Zeb2 knockout (EC<sup>Zeb2KO</sup>) mice a western-type diet (WD). In healthy and steatotic wild-type livers, Zeb2 was ubiquitously and similarly expressed across blood-vascular EC types. LSEC RNA sequencing revealed ZEB2 deficiency-triggered expression changes greatly overlapping with those evoked by WD-feeding. Endothelial Z"],"journal":["Scientific reports"],"pubmed_title":["Loss of endothelial ZEB2 in mice attenuates steatosis early during metabolic dysfunction-associated steatotic liver disease."],"pmcid":["PMC12222841"],"funding_grant_id":["departmental funds","1S25817N","C14/19/095","IUAP/P7/07","2018/23115|ZONMW","H2020-MSCA-IF-REZONABLE658666","FP7-StG-IMAGINED203291","1157318N","1243121N","C12/16/023","PF/10/014","H2020 848109-CRUCIAL","848109","FP7-Health-HemiBio266777","WOG001420N","G.0A3116","BIG project funding"],"pubmed_authors":["Demuynck L","Lox M","van IJcken WFJ","Stroobants M","Jones EAV","Jacquemin M","de Haan W","Van Wauwe J","Huylebroeck D","van Grunsven LA","Dheedene W","Zwijsen A","Vinckier S","Vandervoort P","Lavend'homme R","Martinod K","Verhulst S","Luttun A","Callewaert B","Mulugeta E"],"additional_accession":[]},"is_claimable":false,"name":"Loss of endothelial ZEB2 in mice attenuates steatosis early during metabolic dysfunction-associated steatotic liver disease.","description":"Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, features liver sinusoidal endothelial cell (LSEC) alterations with ill-defined driving factors. Zinc-Finger E-Box-binding Homeobox (ZEB)2 in LSECs preserves their specialized features, prevents capillarization and protects against liver fibrosis. To investigate a potential protective role against steatosis, the initial MASLD stage, we fed EC-specific Zeb2 knockout (EC<sup>Zeb2KO</sup>) mice a western-type diet (WD). In healthy and steatotic wild-type livers, Zeb2 was ubiquitously and similarly expressed across blood-vascular EC types. LSEC RNA sequencing revealed ZEB2 deficiency-triggered expression changes greatly overlapping with those evoked by WD-feeding. Endothelial Z","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-06-02T08:45:00.948Z","creation":"2026-04-16T03:12:51.747Z"},"accession":"S-EPMC12222841","cross_references":{"pubmed":["40603966"],"doi":["10.1038/s41598-025-05881-6"]}}