{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["358(7)"],"submitter":["Platella C"],"funding":["This study is supported by Università degli Studi di Milano: PSR2022_DIP_005_PI_CGIAN.","The research leading to these results has received funding from: (i) Fondazione AIRC under IG 2020-ID.25046- P.I. Montesarchio Daniela; (ii) CN00000041 National Center for Gene Therapy and Drugs based on RNA Technology and the European Union-NextGeneration EU - P.I. Montesarchio Daniela; (iii) Federico II University, FRA2022 project (CUP: E65F22000050001) - P.I. Musumeci Domenica"],"pubmed_abstract":["The synthesis and characterization of a mini-library of cyclic triimidazo triazine (TT) derivatives functionalized with one, two, or three ethynyl-N-methyl-pyridinium moieties are reported here. These compounds were designed with the aim of targeting cancer-related DNA G-quadruplex structures. The newly synthesized compounds were tested for their ability to bind G-quadruplexes from both telomeric and oncogene promoter sequences using an affinity chromatography-based assay, spectroscopic and electrophoretic techniques, as well as molecular docking analysis. The obtained results demonstrated the effective capacity of the investigated compounds to specifically recognize the selected G-quadruplex models, with their TT cores targeting the outer G-quartets and their positively charged N-methyl-p"],"journal":["Archiv der Pharmazie"],"pagination":["e70037"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12223358"],"repository":["biostudies-literature"],"pubmed_title":["Combining Cyclic Triimidazo Triazine Core With Ethynyl-N-Methyl-Pyridinium Groups for Targeting G-Quadruplex Structures."],"pmcid":["PMC12223358"],"pubmed_authors":["Malpicci D","Musumeci D","Montesarchio D","Di Ciolo S","Giannini C","Platella C","Lucenti E","Gaglione R","Arciello A","Cariati E","Criscuolo A"],"additional_accession":[]},"is_claimable":false,"name":"Combining Cyclic Triimidazo Triazine Core With Ethynyl-N-Methyl-Pyridinium Groups for Targeting G-Quadruplex Structures.","description":"The synthesis and characterization of a mini-library of cyclic triimidazo triazine (TT) derivatives functionalized with one, two, or three ethynyl-N-methyl-pyridinium moieties are reported here. These compounds were designed with the aim of targeting cancer-related DNA G-quadruplex structures. The newly synthesized compounds were tested for their ability to bind G-quadruplexes from both telomeric and oncogene promoter sequences using an affinity chromatography-based assay, spectroscopic and electrophoretic techniques, as well as molecular docking analysis. The obtained results demonstrated the effective capacity of the investigated compounds to specifically recognize the selected G-quadruplex models, with their TT cores targeting the outer G-quartets and their positively charged N-methyl-p","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-06-02T05:59:49.401Z","creation":"2026-04-15T03:09:56.097Z"},"accession":"S-EPMC12223358","cross_references":{"pubmed":["40605281"],"doi":["10.1002/ardp.70037"]}}