{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["93(2)"],"submitter":["Kursawe Larsen C"],"funding":["The Danish Environmental Protection Agency under the Ministry of Environments and Food"],"pubmed_abstract":["<h4>Background</h4>Rubber accelerators found in rubber gloves may cause contact allergy and thus allergic contact dermatitis.<h4>Objectives</h4>To investigate which doses of tetraethylthiuram disulfide (TETD) elicit allergic contact dermatitis by patch testing and in a repeated occluded application test simulating glove use.<h4>Patients and methods</h4>A multicentre study was conducted. Eight patients with contact allergy to TETD and eight controls comprised the study group. Doses of TETD 1% (400 μg/cm<sup>2</sup>), 0.33% (130 μg/cm<sup>2</sup>), 0.11% (44 μg/cm<sup>2</sup>), 0.037% (15 μg/cm<sup>2</sup>), 0.012% (4.9 μg/cm<sup>2</sup>), 0.0041% (1.6 μg/cm<sup>2</sup>) and pure vehicle (petrolatum) were used for the patch test. Doses of TETD 1% (39 μg/cm<sup>2</sup>), 0.33% (13 μg/cm<sup>2"],"journal":["Contact dermatitis"],"pagination":["138-147"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12223932"],"repository":["biostudies-literature"],"pubmed_title":["Thresholds for Contact Allergy to a Rubber Accelerator: TETD-Determined by Serial Dilution Patch Testing and a Simulated Glove-Use Model."],"pmcid":["PMC12223932"],"pubmed_authors":["Johansen JD","Kursawe Larsen C","Zachariae C","Schwensen JFB","Bergendorff O","Svedman C","Mortz CG"],"additional_accession":[]},"is_claimable":false,"name":"Thresholds for Contact Allergy to a Rubber Accelerator: TETD-Determined by Serial Dilution Patch Testing and a Simulated Glove-Use Model.","description":"<h4>Background</h4>Rubber accelerators found in rubber gloves may cause contact allergy and thus allergic contact dermatitis.<h4>Objectives</h4>To investigate which doses of tetraethylthiuram disulfide (TETD) elicit allergic contact dermatitis by patch testing and in a repeated occluded application test simulating glove use.<h4>Patients and methods</h4>A multicentre study was conducted. Eight patients with contact allergy to TETD and eight controls comprised the study group. Doses of TETD 1% (400 μg/cm<sup>2</sup>), 0.33% (130 μg/cm<sup>2</sup>), 0.11% (44 μg/cm<sup>2</sup>), 0.037% (15 μg/cm<sup>2</sup>), 0.012% (4.9 μg/cm<sup>2</sup>), 0.0041% (1.6 μg/cm<sup>2</sup>) and pure vehicle (petrolatum) were used for the patch test. Doses of TETD 1% (39 μg/cm<sup>2</sup>), 0.33% (13 μg/cm<sup>2","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-02T10:04:00.835Z","creation":"2026-05-26T03:06:34.548Z"},"accession":"S-EPMC12223932","cross_references":{"pubmed":["40375756"],"doi":["10.1111/cod.14817"]}}