biostudies-literatureUnknown93(2)Kursawe Larsen CThe Danish Environmental Protection Agency under the Ministry of Environments and Food<h4>Background</h4>Rubber accelerators found in rubber gloves may cause contact allergy and thus allergic contact dermatitis.<h4>Objectives</h4>To investigate which doses of tetraethylthiuram disulfide (TETD) elicit allergic contact dermatitis by patch testing and in a repeated occluded application test simulating glove use.<h4>Patients and methods</h4>A multicentre study was conducted. Eight patients with contact allergy to TETD and eight controls comprised the study group. Doses of TETD 1% (400 μg/cm²), 0.33% (130 μg/cm²), 0.11% (44 μg/cm²), 0.037% (15 μg/cm²), 0.012% (4.9 μg/cm²), 0.0041% (1.6 μg/cm²) and pure vehicle (petrolatum) were used for the patch test. Doses of TETD 1% (39 μg/cm²), 0.33% (13 μg/cm<sup>2Contact dermatitis138-147https://www.ebi.ac.uk/biostudies/studies/S-EPMC12223932biostudies-literatureThresholds for Contact Allergy to a Rubber Accelerator: TETD-Determined by Serial Dilution Patch Testing and a Simulated Glove-Use Model.PMC12223932Johansen JDKursawe Larsen CZachariae CSchwensen JFBBergendorff OSvedman CMortz CGfalseThresholds for Contact Allergy to a Rubber Accelerator: TETD-Determined by Serial Dilution Patch Testing and a Simulated Glove-Use Model.<h4>Background</h4>Rubber accelerators found in rubber gloves may cause contact allergy and thus allergic contact dermatitis.<h4>Objectives</h4>To investigate which doses of tetraethylthiuram disulfide (TETD) elicit allergic contact dermatitis by patch testing and in a repeated occluded application test simulating glove use.<h4>Patients and methods</h4>A multicentre study was conducted. Eight patients with contact allergy to TETD and eight controls comprised the study group. Doses of TETD 1% (400 μg/cm²), 0.33% (130 μg/cm²), 0.11% (44 μg/cm²), 0.037% (15 μg/cm²), 0.012% (4.9 μg/cm²), 0.0041% (1.6 μg/cm²) and pure vehicle (petrolatum) were used for the patch test. Doses of TETD 1% (39 μg/cm²), 0.33% (13 μg/cm<sup>22025-01-01T00:00:00Z2025 Aug2026-06-02T10:04:00.835Z2026-05-26T03:06:34.548ZS-EPMC122239324037575610.1111/cod.14817