{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(7)"],"submitter":["Goncalves LT"],"funding":["CAPES/PRINT","Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior"],"pubmed_abstract":["Mitochondria play a central role in cellular respiration, but require close coevolution with the nuclear genome for proper function. This process, termed mitonuclear coevolution, is poorly understood on species-level evolutionary timescales, despite its role in speciation. Here, we investigate mitonuclear coevolution in bumblebees (Bombus), a group of ecologically diverse pollinators with rapid mitochondrial (mt) DNA evolution. Leveraging genomic data from a comprehensive set of 55 bumblebee species, we quantified the evolutionary rate correlation (ERC) between mt genes and nuclear genes that interact with mitochondria (N-mt). We found a strong ERC between mt and N-mt genes, but not among mt genes and random nuclear genes, supporting the mitonuclear coevolution hypothesis. Additionally, we"],"journal":["Genome biology and evolution"],"pagination":["evaf123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12223992"],"repository":["biostudies-literature"],"pubmed_title":["Mitonuclear Coevolution in Bumblebees (Bombus): Genomic Signatures and Its Role in Climatic Niche Adaptation."],"pmcid":["PMC12223992"],"pubmed_authors":["Francoso E","Goncalves LT","Depra M","Pezzi PH"],"additional_accession":[]},"is_claimable":false,"name":"Mitonuclear Coevolution in Bumblebees (Bombus): Genomic Signatures and Its Role in Climatic Niche Adaptation.","description":"Mitochondria play a central role in cellular respiration, but require close coevolution with the nuclear genome for proper function. This process, termed mitonuclear coevolution, is poorly understood on species-level evolutionary timescales, despite its role in speciation. Here, we investigate mitonuclear coevolution in bumblebees (Bombus), a group of ecologically diverse pollinators with rapid mitochondrial (mt) DNA evolution. Leveraging genomic data from a comprehensive set of 55 bumblebee species, we quantified the evolutionary rate correlation (ERC) between mt genes and nuclear genes that interact with mitochondria (N-mt). We found a strong ERC between mt and N-mt genes, but not among mt genes and random nuclear genes, supporting the mitonuclear coevolution hypothesis. Additionally, we","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2025-08-14T03:05:49.353Z","creation":"2025-08-14T03:05:49.353Z"},"accession":"S-EPMC12223992","cross_references":{"pubmed":["40509913"],"doi":["10.1093/gbe/evaf123"]}}