{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Niu G"],"funding":["Ming Wai Lau Centre for Reparative Medicine","Åke Wiberg Stiftelse","Vetenskapsrådet","Swedish National Infrastructure for Computing","Stiftelsen Syskonen Svenssons Stiftelse för Medicinsk Forskning","Welander and Finsens Foundation","Cancerfonden","LEO Fondet","Ragnar Söderbergs stiftelse"],"pagination":["e2416784"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12224929"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(25)"],"pubmed_abstract":["The discovery of an increasing number of translatable circular RNAs (circRNAs) raises the question of whether their coding and non-coding functions can coexist within the same cell. This study profiles the dynamic expression of circRNAs during human skin wound healing. CircGLIS3(2) is identified, a circRNA whose levels transiently rise in dermal fibroblasts of acute wounds and are abnormally overexpressed in keloids, a fibrotic skin condition. Injury signals such as IL-1α, TGF-β, hypoxia, and ER stress induce both expression and cap-independent translation of CircGLIS3(2). The RNA form of CircGLIS3(2) activates fibroblasts into matrix-secreting cells, while its encoded protein promotes cell proliferation, collectively enhancing wound repair. Mechanistically, CircGLIS3(2) RNA stabilizes the"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair."],"pmcid":["PMC12224929"],"funding_grant_id":["2020‐01400","M31/15","No. 20 0930 Pj","23 2832 Pj","2020-01400"],"pubmed_authors":["Toma MA","Wang A","Li D","Schlesinger D","Vegvari A","Xiao Y","Piipponen M","Oasa S","Elsasser SJ","Vij M","Zhang L","Liu Z","Xu Landen N","Wang Q","Luo L","Vukojevic V","Bian X","Chen Y","Geara J","Niu G","Sommar P"],"additional_accession":[]},"is_claimable":false,"name":"Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair.","description":"The discovery of an increasing number of translatable circular RNAs (circRNAs) raises the question of whether their coding and non-coding functions can coexist within the same cell. This study profiles the dynamic expression of circRNAs during human skin wound healing. CircGLIS3(2) is identified, a circRNA whose levels transiently rise in dermal fibroblasts of acute wounds and are abnormally overexpressed in keloids, a fibrotic skin condition. Injury signals such as IL-1α, TGF-β, hypoxia, and ER stress induce both expression and cap-independent translation of CircGLIS3(2). The RNA form of CircGLIS3(2) activates fibroblasts into matrix-secreting cells, while its encoded protein promotes cell proliferation, collectively enhancing wound repair. Mechanistically, CircGLIS3(2) RNA stabilizes the","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-06-02T08:53:33.296Z","creation":"2026-04-16T03:12:38.765Z"},"accession":"S-EPMC12224929","cross_references":{"pubmed":["40279507"],"doi":["10.1002/advs.202416784"]}}