{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Z"],"funding":["National Key Research and Development Program of China"],"pagination":["563"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12225033"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(1)"],"pubmed_abstract":["Estrogen and thyroid hormone interact extensively in vivo, but the relationship between phytoestrogens and thyroid function and thyroid hormone sensitivity remains unclear. Using 2007-2010 NHANES data of United States, we analysed the association of six urinary phytoestrogens with thyroid function and thyroid hormone sensitivity using a weighted multivariate linear regression model. The final analysis included 2521 euthyroid participants. After weighted multivariable adjustment (excluding dietary patterns and serum iodine levels), urinary phytoestrogen concentrations showed significant sex- and compound-specific associations with both thyroid function indicators and thyroid hormone sensitivity indices. For thyroid function, in males, Equol and Enterodiol showed negative associations with f"],"journal":["European journal of medical research"],"pubmed_title":["Urinary phytoestrogen levels and reduced thyroid hormone sensitivity: a cross-sectional analysis of NHANES 2007-2010."],"pmcid":["PMC12225033"],"funding_grant_id":["2020YFC2008905"],"pubmed_authors":["Hu F","Li Z","Yao Y","Lu Y","Yu H"],"additional_accession":[]},"is_claimable":false,"name":"Urinary phytoestrogen levels and reduced thyroid hormone sensitivity: a cross-sectional analysis of NHANES 2007-2010.","description":"Estrogen and thyroid hormone interact extensively in vivo, but the relationship between phytoestrogens and thyroid function and thyroid hormone sensitivity remains unclear. Using 2007-2010 NHANES data of United States, we analysed the association of six urinary phytoestrogens with thyroid function and thyroid hormone sensitivity using a weighted multivariate linear regression model. The final analysis included 2521 euthyroid participants. After weighted multivariable adjustment (excluding dietary patterns and serum iodine levels), urinary phytoestrogen concentrations showed significant sex- and compound-specific associations with both thyroid function indicators and thyroid hormone sensitivity indices. For thyroid function, in males, Equol and Enterodiol showed negative associations with f","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2025-07-28T03:04:19.876Z","creation":"2025-07-28T03:04:19.876Z"},"accession":"S-EPMC12225033","cross_references":{"pubmed":["40604928"],"doi":["10.1186/s40001-025-02800-3"]}}