biostudies-literatureUnknown36(4)Harano KRocheChugai Pharmaceutical<h4>Objective</h4>This post-hoc analysis of the AtTEnd trial explored differences in the prognostic characteristics and in the efficacy of atezolizumab between Asians and non-Asians.<h4>Methods</h4>The role of Asian race was evaluated on progression-free survival (PFS) using Cox-models and on time to appearance of new lesions using Fine and Gray models.<h4>Results</h4>From October 2018 to February 2022, 549 patients were randomized, of whom, 20.4% were Asian. Asians showed a better prognostic profile in terms of age, body mass index, Eastern Cooperative Oncology Group performance status, disease status and previous treatments. The prognostic impact of Asian race on PFS was confirmed in the placebo arm (adjusted hazard ratio [HR]=0.41; 95% confidence interval [CI]=0.24-0.70). In proficient Journal of gynecologic oncologye117https://www.ebi.ac.uk/biostudies/studies/S-EPMC12226327biostudies-literaturePhase III double-blind randomized placebo controlled trial of atezolizumab in combination with carboplatin and paclitaxel in women with advanced/recurrent endometrial carcinoma: the Asian cohort of the AtTEnd/ENGOT-EN7 trial.PMC12226327Pardo BHeitz FArdizzoia ALombard JTakehara KBaldini EECasanova CManso LRabaglio MBarretina-Ginesta MPHarano KFossati RGalli FLee YCLee CUggeri SRedondo ABiagioli ELai CHAu EPalaia IGadducci AKolovetsiou-Kreiner VAllan KHudson ENakagawa SNishio SBologna AAntill YColombo NfalsePhase III double-blind randomized placebo controlled trial of atezolizumab in combination with carboplatin and paclitaxel in women with advanced/recurrent endometrial carcinoma: the Asian cohort of the AtTEnd/ENGOT-EN7 trial.<h4>Objective</h4>This post-hoc analysis of the AtTEnd trial explored differences in the prognostic characteristics and in the efficacy of atezolizumab between Asians and non-Asians.<h4>Methods</h4>The role of Asian race was evaluated on progression-free survival (PFS) using Cox-models and on time to appearance of new lesions using Fine and Gray models.<h4>Results</h4>From October 2018 to February 2022, 549 patients were randomized, of whom, 20.4% were Asian. Asians showed a better prognostic profile in terms of age, body mass index, Eastern Cooperative Oncology Group performance status, disease status and previous treatments. The prognostic impact of Asian race on PFS was confirmed in the placebo arm (adjusted hazard ratio [HR]=0.41; 95% confidence interval [CI]=0.24-0.70). In proficient 2025-01-01T00:00:00Z2025 Jul2026-06-02T10:04:13.551Z2026-05-26T03:06:37.412ZS-EPMC122263274059032610.3802/jgo.2025.36.e117