{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["EPIFEVER-2 investigators"],"funding":["National Institute for Health Research (NIHR)"],"pagination":["134-140"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12226748"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["135(1)"],"pubmed_abstract":["<h4>Background</h4>Genetically predicted higher levels of the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL1-Ra) might reduce the risk of developing epidural-related maternal fever, a phenomenon that occurs exclusively in women having epidural analgesia in labour. We hypothesised that in women having epidural analgesia, the absence of specific alleles that lower circulating levels of IL1-Ra would be associated with the development of epidural-related maternal fever, administration of intrapartum antibiotics, or both.<h4>Methods</h4>We prospectively enrolled women ≥18 yr of age receiving epidural analgesia during labour, excluding those with pre-existing fever, antibiotic therapy, or immunodeficiency. Allele scores were constructed from genotyping the C-allele frequency a"],"journal":["British journal of anaesthesia"],"pubmed_title":["Interleukin-1 receptor antagonist polymorphisms in women receiving epidural analgesia who develop maternal intrapartum fever: a prospective, multicentre Mendelian randomised study."],"pmcid":["PMC12226748"],"funding_grant_id":["NIHR300097"],"pubmed_authors":["Thompson C","Patel A","Rodriguez Sierra EP","Brunnen D","Patrick A","Raja J","Wilson V","Phull M","Stephenson L","Arumugaum A","Razzaque M","Wilson M","Wray S","Tanqueray T","Frowd R","Tripurneni V","Blake H","Weist S","Martin T","Leary R","Canclini L","Wikner M","Kwok S","Kennedy N","Noakes I","De Freixo L","David AL","Achempong Y","Pinder A","Sarmiento L","Borg LX","Berger P","Noblett J","Longbottom R","Carey A","Nicklin A","Begum S","Al-Maiyah F","Hoodless S","Tsun J","Sousi E","Bruce-Hickman K","Mak K","George D","Kim J","Barrett A","Odor P","Costa AV","Valori L","Bourke M","Usman N","Sharp T","Ali A","Abbott TEF","Hoe M","Newth O","Coulter C","Gutierrez Del Arroyo A","Smith C","Waspe J","Wong R","Khan A","Singh A","Ciechanowicz S","Warrington A","Chapman A","Meroz MR","Verma P","Stretch B","Ali J","Quereshi N","Collins E","Folorunsho M","Eiben P","Dias P","Papoutsos C","Vishwanathan A","Sritharan P","Weber V","Das A","Palfreeman C","Mazzoli I","Bramley P","Black R","EPIFEVER-2 investigators","Ackland G"],"additional_accession":[]},"is_claimable":false,"name":"Interleukin-1 receptor antagonist polymorphisms in women receiving epidural analgesia who develop maternal intrapartum fever: a prospective, multicentre Mendelian randomised study.","description":"<h4>Background</h4>Genetically predicted higher levels of the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL1-Ra) might reduce the risk of developing epidural-related maternal fever, a phenomenon that occurs exclusively in women having epidural analgesia in labour. We hypothesised that in women having epidural analgesia, the absence of specific alleles that lower circulating levels of IL1-Ra would be associated with the development of epidural-related maternal fever, administration of intrapartum antibiotics, or both.<h4>Methods</h4>We prospectively enrolled women ≥18 yr of age receiving epidural analgesia during labour, excluding those with pre-existing fever, antibiotic therapy, or immunodeficiency. Allele scores were constructed from genotyping the C-allele frequency a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-26T20:09:33.601Z","creation":"2026-05-26T03:06:33.109Z"},"accession":"S-EPMC12226748","cross_references":{"pubmed":["40368685"],"doi":["10.1016/j.bja.2025.03.037"]}}