{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pongkulapa T"],"funding":["NSF","Grant-in-Aid for Transformative Research Area (A)","NIH R21","Congressionally Directed Medical Research Programs","NHLBI NIH HHS","National Natural Science Foundation of China","Alzheimer's Association","New Jersey Commission on Spinal Cord Research","HealthAdvance","Ovarian Cancer Academy","AMED","Japan Agency for Medical Research and Development","NIDCD NIH HHS","CDMRP","NINDS NIH HHS","NIH RM1","Alzheimer's Association","N.J. Commission on Cancer Research","NIH R01","Japan Society for the Promotion of Science"],"pagination":["e2409530"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12227302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(26)"],"pubmed_abstract":["Precise spatiotemporal control of drug delivery is extremely valuable for regulating stem cell fate, particularly in stem cell differentiation. A novel near-infrared (NIR)-mediated spatiotemporal delivery system is reported combining photo-switchable arylazopyrazole (AAP)-containing DNA strands and upconversion nanoparticles (UCNPs). This nano-drug delivery system (NDDS) enables precise modulation of DNA duplex structures in response to NIR stimuli, overcoming the limitations of traditional UV-responsive systems. AAP derivatives with enhanced photoswitching efficiency (≈98%) and significantly improved cis-form stability are engineered. The successful delivery of curcumin, a neurogenic compound with an affinity for the minor groove of DNA, to human neural stem cells (NSCs) is achieved using"],"journal":["Small (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["NIR-Induced Photoswitching Hybrid DNA Nanoconstruct-Based Drug Delivery System for Spatiotemporal Control of Stem Cell Fate."],"pmcid":["PMC12227302"],"funding_grant_id":["RM1 NS133003-01","1R01NS130836-01A1","RM1 NS133003","R01 DC016612","1R01DC016612","R21 NS132556","22ama121025j0001","3R01DC016612-01S1","AARG‐NTF‐21‐847862","CBET‐1803517","U01 HL150852","CBET-1803517","5R01DC016612-02S1","23H04076","R21 NS132556-01","CSCR16ERG019","R01 NS130836","CSCR17IRG010","NHLBI U01HL150852","AARG-NTF-21-847862","OCRP OC220235P1","COCR23PPR007","OC220235P1"],"pubmed_authors":["Lee KB","Goldston LL","Conklin B","Kumagai T","Sugiyama H","McLoughlin CD","Pongkulapa T","Park S","Yum JH"],"additional_accession":[]},"is_claimable":false,"name":"NIR-Induced Photoswitching Hybrid DNA Nanoconstruct-Based Drug Delivery System for Spatiotemporal Control of Stem Cell Fate.","description":"Precise spatiotemporal control of drug delivery is extremely valuable for regulating stem cell fate, particularly in stem cell differentiation. A novel near-infrared (NIR)-mediated spatiotemporal delivery system is reported combining photo-switchable arylazopyrazole (AAP)-containing DNA strands and upconversion nanoparticles (UCNPs). This nano-drug delivery system (NDDS) enables precise modulation of DNA duplex structures in response to NIR stimuli, overcoming the limitations of traditional UV-responsive systems. AAP derivatives with enhanced photoswitching efficiency (≈98%) and significantly improved cis-form stability are engineered. The successful delivery of curcumin, a neurogenic compound with an affinity for the minor groove of DNA, to human neural stem cells (NSCs) is achieved using","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-07-16T20:24:18.721Z","creation":"2026-07-10T03:09:51.713Z"},"accession":"S-EPMC12227302","cross_references":{"pubmed":["40007062"],"doi":["10.1002/smll.202409530"]}}