{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Jong R"],"funding":["Coalition for Epidemic Preparedness Innovations"],"pagination":["145"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12227699"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["One of the concerns regarding vaccine safety during the COVID-19 pandemic was the potential manifestation of vaccine-associated enhancement of disease (VAED) upon SARS-CoV-2 infection. To investigate the suitability of the Syrian hamster model to test for VAED, we immunized animals with an experimental formaldehyde-inactivated, alum-adjuvanted SARS-CoV-2 vaccine preparation. In two independent experiments, challenge infection did not result in an enhancement of the clinical disease in vaccinated animals compared with mock-vaccinated animals. However, at early timepoints (2-5 days) post-challenge, lung histopathology progressed faster and was more prominent in vaccinated hamsters and lung tissue showed elevated mRNA levels of IL-4 and IL-13. At later time points, cytokine responses and lung"],"journal":["NPJ vaccines"],"pubmed_title":["Hamsters immunized with formalin-inactivated SARS-CoV-2 develop accelerated lung histopathological lesions and Th2-biased response following infection."],"pmcid":["PMC12227699"],"funding_grant_id":["NA"],"pubmed_authors":["de Jong R","Salguero FJ","Hall Y","Oreshkova N","Wiese KE","Vreman S","Carroll M","Bewley KR","de Swart RL","Gonzales JL","Gerhards NM"],"additional_accession":[]},"is_claimable":false,"name":"Hamsters immunized with formalin-inactivated SARS-CoV-2 develop accelerated lung histopathological lesions and Th2-biased response following infection.","description":"One of the concerns regarding vaccine safety during the COVID-19 pandemic was the potential manifestation of vaccine-associated enhancement of disease (VAED) upon SARS-CoV-2 infection. To investigate the suitability of the Syrian hamster model to test for VAED, we immunized animals with an experimental formaldehyde-inactivated, alum-adjuvanted SARS-CoV-2 vaccine preparation. In two independent experiments, challenge infection did not result in an enhancement of the clinical disease in vaccinated animals compared with mock-vaccinated animals. However, at early timepoints (2-5 days) post-challenge, lung histopathology progressed faster and was more prominent in vaccinated hamsters and lung tissue showed elevated mRNA levels of IL-4 and IL-13. At later time points, cytokine responses and lung","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-07-15T06:44:57.954Z","creation":"2025-07-28T03:04:00.413Z"},"accession":"S-EPMC12227699","cross_references":{"pubmed":["40615384"],"doi":["10.1038/s41541-025-01160-7"]}}