{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(4)"],"submitter":["Higashikuni Y"],"pubmed_abstract":["<h4>Background</h4>Cardiomyocyte loss occurs in acute and chronic cardiac injury, including cardiotoxicity due to chemotherapeutics like doxorubicin, and contributes to heart failure development. There is a pressing need for cardiac-specific therapeutics that target cardiomyocyte loss, preventing chemotherapy complications without compromising chemotherapeutic efficacy.<h4>Objectives</h4>The authors employed massively parallel combinatorial genetic screening to find microRNA (miRNA) combinations that promote cardiomyocyte survival.<h4>Methods</h4>CombiGEM (combinatorial genetics en masse) screening in a cardiomyocyte cell line was followed by validation in the original cell type and screening in primary cardiomyocytes. The top combination was tested in mouse and developing zebrafish models"],"journal":["JACC. CardioOncology"],"pagination":["396-410"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12228136"],"repository":["biostudies-literature"],"pubmed_title":["Mitigation of Doxorubicin Cardiotoxicity With Synergistic miRNA Combinations Identified Using Combinatorial Genetics en masse (CombiGEM)."],"pmcid":["PMC12228136"],"pubmed_authors":["Takeda N","Platt C","Obana T","Yeri A","Lu TK","Matsumura T","Bayer AL","Liu W","Uosaki H","Rosenzweig A","Kuznetsov A","Guerra JRB","Tokuyama T","Chen WCW","Higashikuni Y","Turissini C","Shibayama K","Whipple H","Kitchen RR","Asnani AH","Hastings MH","Torizal FG"],"additional_accession":[]},"is_claimable":false,"name":"Mitigation of Doxorubicin Cardiotoxicity With Synergistic miRNA Combinations Identified Using Combinatorial Genetics en masse (CombiGEM).","description":"<h4>Background</h4>Cardiomyocyte loss occurs in acute and chronic cardiac injury, including cardiotoxicity due to chemotherapeutics like doxorubicin, and contributes to heart failure development. There is a pressing need for cardiac-specific therapeutics that target cardiomyocyte loss, preventing chemotherapy complications without compromising chemotherapeutic efficacy.<h4>Objectives</h4>The authors employed massively parallel combinatorial genetic screening to find microRNA (miRNA) combinations that promote cardiomyocyte survival.<h4>Methods</h4>CombiGEM (combinatorial genetics en masse) screening in a cardiomyocyte cell line was followed by validation in the original cell type and screening in primary cardiomyocytes. The top combination was tested in mouse and developing zebrafish models","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-02T20:17:45.294Z","creation":"2026-04-20T03:10:07.849Z"},"accession":"S-EPMC12228136","cross_references":{"pubmed":["40366325"],"doi":["10.1016/j.jaccao.2025.03.007"]}}