{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["334(7)"],"submitter":["Miao Z"],"pubmed_abstract":["<h4>Importance</h4>The role of intra-arterial tenecteplase for acute large vessel occlusion (LVO) stroke after successful endovascular therapy is uncertain.<h4>Objective</h4>To assess the efficacy and safety of intra-arterial tenecteplase in patients with successful endovascular therapy (defined as a score on the expanded Thrombolysis in Cerebral Infarction [eTICI] scale of 2b to 3) after endovascular therapy.<h4>Design, setting, and participants</h4>This was a prospective, open-label, blinded end point, randomized trial. Recruitment took place between February 16, 2023, and March 23, 2024, with final follow-up on July 4, 2024. The study was conducted across 19 centers in China. Patients with acute anterior circulation LVO treated between 4.5 and 24 hours from the time that the patient was"],"journal":["JAMA"],"pagination":["582-591"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12228980"],"repository":["biostudies-literature"],"pubmed_title":["Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy: The ANGEL-TNK Randomized Clinical Trial."],"pmcid":["PMC12228980"],"pubmed_authors":["Hao J","Wang B","Lu X","Zhang H","Zhang L","Wang J","Gao F","Xiong Y","Liebeskind DS","Sun D","Chen W","Wen C","Nan G","Wang W","Chen Y","Wang Y","Wu W","Deng Y","Sheng Y","Chen K","Xie X","Liao X","Yang M","Xu C","Yao X","Sun X","Yuan G","Sun Y","Li X","Li Z","Li S","He Z","Huo X","Yao C","Gao W","Yang Q","Long D","Mo D","Jing J","Liu L","Ma N","Ren Z","Jia B","Jie F","Feng G","Xiang G","Liu T","Yi T","Yu H","Zhao X","Song L","Liu Y","Wei M","Nguyen TN","Zhao J","Zhao H","Chang M","Zhou L","Pan Y","Yan J","Zhou Q","Luo G","ANGEL-TNK Investigators","Tong X","Zhou Z","Zhang Z","Zhang X","Han H","Liu B","Yan B","Han J","Jovin TG","Yan H","Miao Z","Cai X","Ma G"],"additional_accession":[]},"is_claimable":false,"name":"Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy: The ANGEL-TNK Randomized Clinical Trial.","description":"<h4>Importance</h4>The role of intra-arterial tenecteplase for acute large vessel occlusion (LVO) stroke after successful endovascular therapy is uncertain.<h4>Objective</h4>To assess the efficacy and safety of intra-arterial tenecteplase in patients with successful endovascular therapy (defined as a score on the expanded Thrombolysis in Cerebral Infarction [eTICI] scale of 2b to 3) after endovascular therapy.<h4>Design, setting, and participants</h4>This was a prospective, open-label, blinded end point, randomized trial. Recruitment took place between February 16, 2023, and March 23, 2024, with final follow-up on July 4, 2024. The study was conducted across 19 centers in China. Patients with acute anterior circulation LVO treated between 4.5 and 24 hours from the time that the patient was","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-09T05:44:21.66Z","creation":"2026-06-09T03:07:48.038Z"},"accession":"S-EPMC12228980","cross_references":{"pubmed":["40616323"],"doi":["10.1001/jama.2025.10800"]}}