{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sosa M"],"funding":["Simons Foundation","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)","Howard Hughes Medical Institute","NIDA NIH HHS","NIMH NIH HHS","Helen Hay Whitney Foundation (HHWF)","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","James S. McDonnell Foundation","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","Howard Hughes Medical Institute (HHMI)","James S. McDonnell Foundation (McDonnell Foundation)","Vallee Foundation (Bert L. & N. Kuggie Vallee Foundation)","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","Vallee Foundation","NINDS NIH HHS","Helen Hay Whitney Foundation"],"pagination":["1497-1509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12229899"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(7)"],"pubmed_abstract":["To reinforce rewarding behaviors, events leading up to and following rewards must be remembered. Hippocampal place cell activity spans spatial and non-spatial episodes, but whether hippocampal activity encodes entire sequences of events relative to reward is unknown. Here, to test this possibility, we performed two-photon imaging of hippocampal CA1 as mice navigated virtual environments with changing hidden reward locations. We found that when the reward moved, a subpopulation of neurons updated their firing fields to the same relative position with respect to reward, constructing behavioral timescale sequences spanning the entire task. Over learning, this reward-relative representation became more robust as additional neurons were recruited, and changes in reward-relative firing often pre"],"journal":["Nature neuroscience"],"pubmed_title":["A flexible hippocampal population code for experience relative to reward."],"pmcid":["PMC12229899"],"funding_grant_id":["K99MH135993","NA","542987SPI","P50 DA042012","1R01MH126904-01A1","R01 MH126904","R01 MH130452","), BRAIN Initiative U19NS118284","U19 NS118284","R01MH130452","K99 MH135993"],"pubmed_authors":["Sosa M","Plitt MH","Giocomo LM"],"additional_accession":[]},"is_claimable":false,"name":"A flexible hippocampal population code for experience relative to reward.","description":"To reinforce rewarding behaviors, events leading up to and following rewards must be remembered. Hippocampal place cell activity spans spatial and non-spatial episodes, but whether hippocampal activity encodes entire sequences of events relative to reward is unknown. Here, to test this possibility, we performed two-photon imaging of hippocampal CA1 as mice navigated virtual environments with changing hidden reward locations. We found that when the reward moved, a subpopulation of neurons updated their firing fields to the same relative position with respect to reward, constructing behavioral timescale sequences spanning the entire task. Over learning, this reward-relative representation became more robust as additional neurons were recruited, and changes in reward-relative firing often pre","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-16T00:44:49.453Z","creation":"2025-08-15T03:06:39.371Z"},"accession":"S-EPMC12229899","cross_references":{"pubmed":["40500314"],"doi":["10.1038/s41593-025-01985-4"]}}