{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(7)"],"submitter":["Li M"],"funding":["Changping Laboratory"],"pubmed_abstract":["<h4>Introduction</h4>Depression is characterised by disruptions in brain circuitry, and interventions like intermittent theta burst stimulation (iTBS) offer the potential for normalising these circuits and improving clinical symptoms. However, personalised treatment targets for depression remain underexplored. This trial aims to evaluate the clinical efficacy of iTBS as an additional treatment to a stable antidepressant regimen in patients with treatment-resistant depression (TRD) by modulating brain circuits identified through personalized brain functional sectors compared with sham treatment. This work is a part of the China Study to Predict Optimised Treatment bioMarkers of Individualised Neuromodulation in Depression project.<h4>Methods and analysis</h4>This is a multi-centre, double-b"],"journal":["BMJ open"],"pagination":["e098155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12230962"],"repository":["biostudies-literature"],"pubmed_title":["Personalized brain functional sectors guided theta burst transcranial magnetic stimulation for treatment-resistant depression: a study protocol for a multi-centre, randomised, double-blind, sham-controlled clinical trial."],"pmcid":["PMC12230962"],"pubmed_authors":["Liang S","Liu H","Zhang D","Hu Y","Gong Q","Wang G","Zhang L","Qin W","Wang K","Zhang P","Wang M","Jiang Y","Cheng H","Xie W","Kuang W","Ji G","Chen L","Sun X","Li L","Li M","Yang Z","Li Z","Yu C","Zhang Y","Yue W"],"additional_accession":[]},"is_claimable":false,"name":"Personalized brain functional sectors guided theta burst transcranial magnetic stimulation for treatment-resistant depression: a study protocol for a multi-centre, randomised, double-blind, sham-controlled clinical trial.","description":"<h4>Introduction</h4>Depression is characterised by disruptions in brain circuitry, and interventions like intermittent theta burst stimulation (iTBS) offer the potential for normalising these circuits and improving clinical symptoms. However, personalised treatment targets for depression remain underexplored. This trial aims to evaluate the clinical efficacy of iTBS as an additional treatment to a stable antidepressant regimen in patients with treatment-resistant depression (TRD) by modulating brain circuits identified through personalized brain functional sectors compared with sham treatment. This work is a part of the China Study to Predict Optimised Treatment bioMarkers of Individualised Neuromodulation in Depression project.<h4>Methods and analysis</h4>This is a multi-centre, double-b","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-06-12T04:45:45.545Z","creation":"2026-06-12T03:07:41.519Z"},"accession":"S-EPMC12230962","cross_references":{"pubmed":["40623739"],"doi":["10.1136/bmjopen-2024-098155"]}}