{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Lee BN"],"funding":["Intramural NIH HHS","NIDDK NIH HHS","NHLBI NIH HHS"],"pubmed_abstract":["Human induced pluripotent stem cells (iPSCs) have transformed biomedical research by enabling the generation of diverse cell types from accessible somatic tissues. However, certain fundamental biological properties, such as the genetic and epigenetic determinants of iPSC proliferation, remain poorly characterized. We measured the growth of iPSC lines derived from 602 unique donors using high-throughput time-lapse imaging, quantified proliferation through a growth Area-Under-the-Curve (gAUC) phenotype, and correlated gAUC with the gene expression and genotype of the cell lines. We identified 3,091 genes associated with gAUC, many of which are well established regulators of cell proliferation. We also found that rare deleterious variants in <i>WDR54</i> were associated with reduced iPSC grow"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.07.02.662844"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12236597"],"repository":["biostudies-literature"],"pubmed_title":["Genetics of growth rate in induced pluripotent stem cells."],"pmcid":["PMC12236597"],"funding_grant_id":["R01 DK116750","R01 DK106236","P30 DK116074","R01 DK120565","R01 DK137889","U01 HL107388","U01 HL107442","DP3 DK112155","ZIA HG000024"],"pubmed_authors":["Robertson CC","Parsaud H","Narisu N","Carcamo-Orive I","GENESiPS Consortium","Cipriani F","Taylor HJ","iPSCORE Consortium","Sinha N","Frazer KA","Butt A","Dale N","Knowles JW","Erdos MR","NYSCF Global Stem Cell Array Team","Yan T","Bonnycastle LL","Lee BN","D'Antonio-Chronowska A","Swift AJ","Taylor DL","Paull D","Semrau S","Biesecker LG","Noggle S","Collins FS"],"additional_accession":[]},"is_claimable":false,"name":"Genetics of growth rate in induced pluripotent stem cells.","description":"Human induced pluripotent stem cells (iPSCs) have transformed biomedical research by enabling the generation of diverse cell types from accessible somatic tissues. However, certain fundamental biological properties, such as the genetic and epigenetic determinants of iPSC proliferation, remain poorly characterized. We measured the growth of iPSC lines derived from 602 unique donors using high-throughput time-lapse imaging, quantified proliferation through a growth Area-Under-the-Curve (gAUC) phenotype, and correlated gAUC with the gene expression and genotype of the cell lines. We identified 3,091 genes associated with gAUC, many of which are well established regulators of cell proliferation. We also found that rare deleterious variants in <i>WDR54</i> were associated with reduced iPSC grow","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-04-08T11:46:41.161Z","creation":"2026-04-08T02:07:55.245Z"},"accession":"S-EPMC12236597","cross_references":{"pubmed":["40631191"],"doi":["10.1101/2025.07.02.662844"]}}