{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Billmann M"],"funding":["NHGRI NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["We generated a genome-scale, genetic interaction network from the analysis of more than 4 million double mutants in the haploid human cell line, HAP1. The network maps ~90,000 genetic interactions, including thousands of extreme synthetic lethal and genetic suppression interactions. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to protein complexes, pathways, biological processes, and cellular compartments. Comparative analyses showed that general principles of genetic networks are conserved from yeast to human cells. A genetic interaction network mapped in a single genetic background complements the DepMap gene co-essentiality network, recapitulating many of the same biological connections and also capturing unique "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.06.30.662193"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12236771"],"repository":["biostudies-literature"],"pubmed_title":["A global genetic interaction map of a human cell reveals conserved principles of genetic networks."],"pmcid":["PMC12236771"],"funding_grant_id":["R01 HG005084","T32 GM008347","F30 CA257227"],"pubmed_authors":["Roth FP","Ubhi T","Liang W","Lu X","Brown GW","Brown KR","Varland S","Caumanns JJ","Lawson KA","Chan KS","Pons C","Mikolajewicz N","Wang W","Nixon A","Tong AHY","Thomson Taylor D","Schultz E","Dasgupta K","Tan G","Tieu D","Aulakh K","Boone C","Chandrashekhar M","Rahman M","Rojas Echenique JI","Xia T","Roth AF","Rohde T","Ward HN","Nami B","Hassan AZ","Aregger M","Sizova O","Gacesa R","Xiao YX","Lin K","Almeida SMT","Wyatt HDM","Billmann M","Andrews B","Mero P","Soste M","Loewith R","Aguilera-Uribe M","Myers CL","Costanzo M","Mair B","Nedyalkova L","Rost HL","Climie R","Kantautas K","Bader GD","Usaj M","Chang D","Wei J","Wang ZY","Ross C","Bhojoo U","Birkadze S","Shuteriqi E","Drazic A","Ji F","Cravatt BF","Budijono N","Turowec J","van Leeuwen J","Granda Farias A","Kim DK","Horecka I","Davis NG","Lee SY","Forster D","Wang KE","Zhang X","Habsid A","Tereshchenko M","Dixon SJ","Moffat J","Lim J","Sartori Rodrigues M","Lee Y","Cai X","Seetharaman A","Sen NE","Masud SN"],"additional_accession":[]},"is_claimable":false,"name":"A global genetic interaction map of a human cell reveals conserved principles of genetic networks.","description":"We generated a genome-scale, genetic interaction network from the analysis of more than 4 million double mutants in the haploid human cell line, HAP1. The network maps ~90,000 genetic interactions, including thousands of extreme synthetic lethal and genetic suppression interactions. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to protein complexes, pathways, biological processes, and cellular compartments. Comparative analyses showed that general principles of genetic networks are conserved from yeast to human cells. A genetic interaction network mapped in a single genetic background complements the DepMap gene co-essentiality network, recapitulating many of the same biological connections and also capturing unique ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-23T03:28:21.037Z","creation":"2026-05-23T03:14:09.185Z"},"accession":"S-EPMC12236771","cross_references":{"pubmed":["40631273"],"doi":["10.1101/2025.06.30.662193"]}}