biostudies-literatureUnknown68(1)Ma H<h4>Background</h4>Rotavirus (RV) A is one of the major reasons which causes acute dehydration and diarrhea. It is also one of the highest morbid diseases in children. There are only a few reports about the changes in prevalence and VP4/VP7 genotype of RVs in southwest China. Here is the report about the prevalence of RVs from 2015 to 2020 in Yunnan, southwest China.<h4>Methods</h4>The virus genes were extracted from RV positive samples, then VP4/VP7 genes were amplified, followed by sequencing and gene typing, phylogenetic analysis, antigenic epitope variation analysis, and selective pressure analysis were also performed.<h4>Results</h4>A total of 135 VP4 gene sequences and 143 VP7 gene sequences were obtained from stool samples during 2015-2020. Of them, P[8] genotype accounted for 97.0%Intervirology43-56https://www.ebi.ac.uk/biostudies/studies/S-EPMC12237282biostudies-literatureGenetic and Antigenic Variability in VP4 and VP7 of Group A Human Rotavirus in Yunnan, China, from 2015 to 2020.PMC12237282Wang MZhao CSun QZhang ZJiang HMa HChuan LLong SQiu LfalseGenetic and Antigenic Variability in VP4 and VP7 of Group A Human Rotavirus in Yunnan, China, from 2015 to 2020.<h4>Background</h4>Rotavirus (RV) A is one of the major reasons which causes acute dehydration and diarrhea. It is also one of the highest morbid diseases in children. There are only a few reports about the changes in prevalence and VP4/VP7 genotype of RVs in southwest China. Here is the report about the prevalence of RVs from 2015 to 2020 in Yunnan, southwest China.<h4>Methods</h4>The virus genes were extracted from RV positive samples, then VP4/VP7 genes were amplified, followed by sequencing and gene typing, phylogenetic analysis, antigenic epitope variation analysis, and selective pressure analysis were also performed.<h4>Results</h4>A total of 135 VP4 gene sequences and 143 VP7 gene sequences were obtained from stool samples during 2015-2020. Of them, P[8] genotype accounted for 97.0%2025-01-01T00:00:00Z20252026-07-15T12:44:44.244Z2026-07-04T03:16:24.995ZS-EPMC122372824030056210.1159/000546065