biostudies-literatureUnknownWang YMinistry of Health, Labour and WelfareNational Center for Global Health and MedicineJapan Society for the Promotion of ScienceIndustrial Health Foundation<h4>Background</h4>While evidence from Western countries links low-to-moderate alcohol consumption to a lower risk of type 2 diabetes mellitus (T2D), findings have been inconsistent in Asia. Since T2D in Asia involves both insulin resistance and deficient insulin secretion, both of which are differently affected by alcohol, we prospectively examined whether the association differs according to body mass index (BMI) categories among the Japanese.<h4>Methods</h4>Participants were 31,524 health checkup examinees (26,819 males and 4,705 females aged 20-64 years) who were free from diabetes at baseline. Self-reported data on alcohol use were used to estimate the average daily alcohol consumption at the baseline. Incident diabetes was identified at annual checkups during the follow-up period. A Journal of epidemiologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC12237586biostudies-literatureAssociation between alcohol consumption and the risk of type 2 diabetes mellitus across different body mass index categories among Japanese workers.PMC12237586170301-01JP20K2328028-shi-1206140202-0122A1008150903-01JP16H05251JP2570200619A100630-Shi-200321A1020JP25293146Yamamoto SFukunaga AHayashi TNakagawa TWang YKonishi MInoue YHonda TMizoue TfalseAssociation between alcohol consumption and the risk of type 2 diabetes mellitus across different body mass index categories among Japanese workers.<h4>Background</h4>While evidence from Western countries links low-to-moderate alcohol consumption to a lower risk of type 2 diabetes mellitus (T2D), findings have been inconsistent in Asia. Since T2D in Asia involves both insulin resistance and deficient insulin secretion, both of which are differently affected by alcohol, we prospectively examined whether the association differs according to body mass index (BMI) categories among the Japanese.<h4>Methods</h4>Participants were 31,524 health checkup examinees (26,819 males and 4,705 females aged 20-64 years) who were free from diabetes at baseline. Self-reported data on alcohol use were used to estimate the average daily alcohol consumption at the baseline. Incident diabetes was identified at annual checkups during the follow-up period. A 2025-01-01T00:00:00Z2025 Feb2026-03-27T15:57:47.54Z2025-08-27T03:07:01.138ZS-EPMC122375863992424810.2188/jea.JE20240259