{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gu W"],"funding":["Science and Technology Plan Project in Guangzhou","National Natural Science Foundation of China"],"pagination":["e0101625"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12239582"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(7)"],"pubmed_abstract":["<i>Dickeya oryzae</i> is a prevalent pathogen capable of infecting a variety of crops and plants, and its cell motility plays a key role in invasion of host and subsequent systemic infection. We recently demonstrated that the bacterial second messenger c-di-GMP and the putrescine (PUT)-mediated quorum sensing (QS) system are, respectively, involved in negative and positive regulation of bacterial motility, and vice versa, biofilm formation. In this study, we aimed to investigate the potential interaction of these two signaling mechanisms in the modulation of bacterial motility. The results indicated that null mutation of the PUT system did not seem to have much effect on the cellular level of c-di-GMP; however, deletion of the genes encoding c-di-GMP degradation led to a significant reduct"],"journal":["mBio"],"pubmed_title":["The cyclic di-GMP receptor YcgR links the second messenger with the putrescine quorum sensing system in modulation of &lt;i&gt;Dickeya oryzae&lt;/i&gt; motility."],"pmcid":["PMC12239582"],"funding_grant_id":["2025A04J7118","32102155","U22A20480"],"pubmed_authors":["Liao L","Chen Z","Zhu Y","Zhang L-h","Gu W","Chen Y","Gao H","Xie C"],"additional_accession":[]},"is_claimable":false,"name":"The cyclic di-GMP receptor YcgR links the second messenger with the putrescine quorum sensing system in modulation of &lt;i&gt;Dickeya oryzae&lt;/i&gt; motility.","description":"<i>Dickeya oryzae</i> is a prevalent pathogen capable of infecting a variety of crops and plants, and its cell motility plays a key role in invasion of host and subsequent systemic infection. We recently demonstrated that the bacterial second messenger c-di-GMP and the putrescine (PUT)-mediated quorum sensing (QS) system are, respectively, involved in negative and positive regulation of bacterial motility, and vice versa, biofilm formation. In this study, we aimed to investigate the potential interaction of these two signaling mechanisms in the modulation of bacterial motility. The results indicated that null mutation of the PUT system did not seem to have much effect on the cellular level of c-di-GMP; however, deletion of the genes encoding c-di-GMP degradation led to a significant reduct","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-07-15T10:54:50.214Z","creation":"2026-07-03T03:15:41.683Z"},"accession":"S-EPMC12239582","cross_references":{"pubmed":["40444987"],"doi":["10.1128/mbio.01016-25"]}}