{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["59"],"submitter":["Duan H"],"pubmed_abstract":["Colorectal cancer (CRC) is among top most common cancers with high mortality rate and major health issue yet to resolve across the globe. miR-23b is an oncogene in many cancers including CRC. The route of involvement of miR-23b in the regulation of CRC is still unclear. Study explored bioregulatory mechanism of miR-23b against CRC involving in vitro and animal model experimentation via experimentation involving ki67 immunohistochemistry, CCK8, EDU, and Transwell cell migration. The bioinformatic studies were employed to predict miR-23b target tumor suppressor PTPRG while the luciferase reporter gene assay was used to find the binding capabilities of miR-23b to the 3'-UTR of PTPRG. The changes in the expression of miR-23b were found in three CRC cell lines including SW480, HT29, and Caco2, "],"journal":["Translational oncology"],"pagination":["102447"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12240168"],"repository":["biostudies-literature"],"pubmed_title":["miR-23b is a negative regulator of tumor suppressing PTPRG in colorectal cancer."],"pmcid":["PMC12240168"],"pubmed_authors":["Yang J","He C","Wang T","Li F","Hu H","Zhai K","Zhang S","Khan GJ","Duan H","Jia J","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"miR-23b is a negative regulator of tumor suppressing PTPRG in colorectal cancer.","description":"Colorectal cancer (CRC) is among top most common cancers with high mortality rate and major health issue yet to resolve across the globe. miR-23b is an oncogene in many cancers including CRC. The route of involvement of miR-23b in the regulation of CRC is still unclear. Study explored bioregulatory mechanism of miR-23b against CRC involving in vitro and animal model experimentation via experimentation involving ki67 immunohistochemistry, CCK8, EDU, and Transwell cell migration. The bioinformatic studies were employed to predict miR-23b target tumor suppressor PTPRG while the luciferase reporter gene assay was used to find the binding capabilities of miR-23b to the 3'-UTR of PTPRG. The changes in the expression of miR-23b were found in three CRC cell lines including SW480, HT29, and Caco2, ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-03-15T14:00:58.242Z","creation":"2025-08-13T03:04:29.089Z"},"accession":"S-EPMC12240168","cross_references":{"pubmed":["40561798"],"doi":["10.1016/j.tranon.2025.102447"]}}