biostudies-literatureHandoko KNIMHNCATS NIH HHSNIMH NIH HHSNINDS NIH HHSPitt CTSININDS794-803https://www.ebi.ac.uk/biostudies/studies/S-EPMC12246166biostudies-literatureUnknown10(8)<h4>Background</h4>Acute experimental models of antidepressant placebo effects suggest that expectancies, encoded within the salience network (SN), are reinforced by sensory evidence and mood fluctuations. However, whether these dynamics extend to longer timescales remains unknown. To answer this question, we investigated how SN and default mode network (DMN) functional connectivity during the processing of antidepressant expectancies facilitates the shift from salience attribution to contextual cues in the SN to belief-induced mood responses in the DMN, both acutely and long term.<h4>Methods</h4>Sixty psychotropic-free patients with major depressive disorder completed an acute antidepressant placebo functional magnetic resonance imaging experiment manipulating placebo-associated expectancBiological psychiatry. Cognitive neuroscience and neuroimagingExpectancy-Mood Neural Dynamics Predict Mechanisms of Short- and Long-Term Antidepressant Placebo Effects.PMC12246166K23 MH108674R01 MH122548R01 MH048463R01 MH100095R25 NS088248UL1 TR001857Pecina MSnyder IKarim HTHandoko KNeppach ADombrovski AYfalseExpectancy-Mood Neural Dynamics Predict Mechanisms of Short- and Long-Term Antidepressant Placebo Effects.<h4>Background</h4>Acute experimental models of antidepressant placebo effects suggest that expectancies, encoded within the salience network (SN), are reinforced by sensory evidence and mood fluctuations. However, whether these dynamics extend to longer timescales remains unknown. To answer this question, we investigated how SN and default mode network (DMN) functional connectivity during the processing of antidepressant expectancies facilitates the shift from salience attribution to contextual cues in the SN to belief-induced mood responses in the DMN, both acutely and long term.<h4>Methods</h4>Sixty psychotropic-free patients with major depressive disorder completed an acute antidepressant placebo functional magnetic resonance imaging experiment manipulating placebo-associated expectanc2025-01-01T00:00:00Z2025 Aug2026-06-06T11:44:41.294Z2026-05-30T03:07:19.888ZS-EPMC122461663980555510.1016/j.bpsc.2025.01.002