biostudies-literatureMiller AMNCI NIH HHS979-988https://www.ebi.ac.uk/biostudies/studies/S-EPMC12247493biostudies-literatureUnknown21(7)<h4>Purpose</h4>This study aimed to determine complete toxicity reporting (CTR), and the use of subjective toxicity-minimizing language (TML) among phase III oncology trials.<h4>Methods</h4>Two-arm superiority-design phase III oncology trials published from 2002 to 2020 were reviewed for toxicity data. CTR was defined as reporting total adverse events (TAEs), total serious adverse events (SAEs), total deaths, and study therapy discontinuations because of toxicity. Guideline concordance was defined according to guidelines published in the <i>BMJ</i> (defined as reporting total SAEs, total deaths, and study therapy discontinuations because of toxicity). TML was defined as a set of terms that subjectively downplay the harm of therapies.<h4>Results</h4>A total of 407 trials enrolling 322,645 pJCO oncology practiceIncomplete Toxicity Reporting and Use of Toxicity-Minimizing Language in Phase III Oncology Trials.PMC12247493P30 CA016672Abi Jaoude JKupferman GSBeck EJMiller AMKouzy RLin TALudmir EBMsaouel PPassy AHSherry ADfalseIncomplete Toxicity Reporting and Use of Toxicity-Minimizing Language in Phase III Oncology Trials.<h4>Purpose</h4>This study aimed to determine complete toxicity reporting (CTR), and the use of subjective toxicity-minimizing language (TML) among phase III oncology trials.<h4>Methods</h4>Two-arm superiority-design phase III oncology trials published from 2002 to 2020 were reviewed for toxicity data. CTR was defined as reporting total adverse events (TAEs), total serious adverse events (SAEs), total deaths, and study therapy discontinuations because of toxicity. Guideline concordance was defined according to guidelines published in the <i>BMJ</i> (defined as reporting total SAEs, total deaths, and study therapy discontinuations because of toxicity). TML was defined as a set of terms that subjectively downplay the harm of therapies.<h4>Results</h4>A total of 407 trials enrolling 322,645 p2025-01-01T00:00:00Z2025 Jul2026-06-06T19:33:22.752Z2026-06-04T03:10:39.325ZS-EPMC122474933977812210.1200/OP-24-0073510.1200/op-24-00735