{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brown TT"],"funding":["NIAID NIH HHS"],"pagination":["983-986"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12249367"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81(5)"],"pubmed_abstract":["In a randomized clinical trial, pre-exposure prophylaxis (PrEP) with long-acting cabotegravir (CAB-LA) had a better bone safety profile than tenofovir disoproxil fumarate-emtricitabine (TDF-FTC) over 105 weeks. For individuals with low bone mineral density or other fracture risk factors, CAB-LA PrEP should be considered over TDF-based PrEP. Clinical Trials Registration.  clinicaltrials.gov (NCT02720094)."],"journal":["Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"],"pubmed_title":["Bone Changes With Long-Acting Cabotegravir or Tenofovir Disoproxil Fumarate/Emtricitabine for HIV Prevention in Cisgender Men and Transgender Women: HPTN 083."],"pmcid":["PMC12249367"],"funding_grant_id":["UM1 AI069424","UM1 AI068613","UM1 AI068636","UM1 AI068617","UM1 AI068619","U01 AI069476","UM1 AI069476"],"pubmed_authors":["Rinehart AR","Oyedele T","Landovitz RJ","Hanscom B","Vasconcelos R","Warsi M","McCauley M","Rooney JF","Arao RF","Sullivan PA","Brown TT","Grinsztejn B","Phanuphak N"],"additional_accession":[]},"is_claimable":false,"name":"Bone Changes With Long-Acting Cabotegravir or Tenofovir Disoproxil Fumarate/Emtricitabine for HIV Prevention in Cisgender Men and Transgender Women: HPTN 083.","description":"In a randomized clinical trial, pre-exposure prophylaxis (PrEP) with long-acting cabotegravir (CAB-LA) had a better bone safety profile than tenofovir disoproxil fumarate-emtricitabine (TDF-FTC) over 105 weeks. For individuals with low bone mineral density or other fracture risk factors, CAB-LA PrEP should be considered over TDF-based PrEP. Clinical Trials Registration.  clinicaltrials.gov (NCT02720094).","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T17:44:05.241Z","creation":"2026-06-03T03:10:34.902Z"},"accession":"S-EPMC12249367","cross_references":{"pubmed":["40590452"],"doi":["10.1093/cid/ciaf221"]}}