{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang L"],"funding":["the National Key Research and Development Program-Key Projects","the National Natural Science Foundation of China"],"pagination":["6224"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12250145"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(13)"],"pubmed_abstract":["Tan sheep outperform Dorper sheep in meat-quality traits, including muscle fiber characteristics and fatty acid composition, while Dorper sheep excel in carcass weight. However, the molecular mechanisms underlying these breed-specific traits, especially gut microbiota-bile acid (BA) interactions, remain poorly understood. As host-microbiota co-metabolites, BAs are converted by colonic microbiota via bile salt hydrolase (BSH) and dehydroxylases into secondary BAs, which activate BA receptors to regulate host lipid and glucose metabolism. This study analyzed colonic BA profiles in 8-month-old Tan and Dorper sheep, integrating microbiome and longissimus dorsi muscle transcriptome data to investigate the gut-muscle axis in meat-quality and carcass trait regulation. Results showed that Tan shee"],"journal":["International journal of molecular sciences"],"pubmed_title":["Gut Microbiota-Bile Acid Crosstalk Contributes to Meat Quality and Carcass Traits of Tan and Dorper Sheep."],"pmcid":["PMC12250145"],"funding_grant_id":["2021YFD1200900","U21A20246"],"pubmed_authors":["Yang X","Li Z","Yang L","Lv F","Xue P","Xue M","Zhang L","Fang M","Chan S","Cui R"],"additional_accession":[]},"is_claimable":false,"name":"Gut Microbiota-Bile Acid Crosstalk Contributes to Meat Quality and Carcass Traits of Tan and Dorper Sheep.","description":"Tan sheep outperform Dorper sheep in meat-quality traits, including muscle fiber characteristics and fatty acid composition, while Dorper sheep excel in carcass weight. However, the molecular mechanisms underlying these breed-specific traits, especially gut microbiota-bile acid (BA) interactions, remain poorly understood. As host-microbiota co-metabolites, BAs are converted by colonic microbiota via bile salt hydrolase (BSH) and dehydroxylases into secondary BAs, which activate BA receptors to regulate host lipid and glucose metabolism. This study analyzed colonic BA profiles in 8-month-old Tan and Dorper sheep, integrating microbiome and longissimus dorsi muscle transcriptome data to investigate the gut-muscle axis in meat-quality and carcass trait regulation. Results showed that Tan shee","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-06-30T03:28:23.143Z","creation":"2026-06-30T03:22:13.317Z"},"accession":"S-EPMC12250145","cross_references":{"pubmed":["40650015"],"doi":["10.3390/ijms26136224"]}}