{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cooper C"],"funding":["Bundesministerium für Bildung und Forschung","Deutsche Forschungsgemeinschaft","European Research Council"],"pagination":["RP101105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12252544"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Beyond the vast array of functional roles attributed to serotonin (5-HT) in the brain, changes in 5-HT levels have been shown to accompany changes in behavioral states, including WAKE, NREM, and REM sleep. Whether 5-HT dynamics at shorter time scales can be seen to delineate substates within these larger brain states remains an open question. Here, we performed simultaneous recordings of extracellular 5-HT using a recently developed G-Protein-Coupled Receptor-Activation-Based 5-HT sensor (GRAB5-HT3.0) and local field potential in the hippocampal CA1 of mice, which revealed the presence of prominent ultraslow (<0.05 Hz) 5-HT oscillations both during NREM and WAKE states. Interestingly, the phase of these ultraslow 5-HT oscillations was found to distinguish substates both within and across l"],"journal":["eLife"],"pubmed_title":["Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking."],"pmcid":["PMC12252544"],"funding_grant_id":["10.3030/810580","431572356","327654276","Exc-2049-390688087","01GQ1420B","184695641"],"pubmed_authors":["Tukker JJ","Tritsch N","Schmitz D","Cooper C","Parthier D","Sibille J"],"additional_accession":[]},"is_claimable":false,"name":"Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking.","description":"Beyond the vast array of functional roles attributed to serotonin (5-HT) in the brain, changes in 5-HT levels have been shown to accompany changes in behavioral states, including WAKE, NREM, and REM sleep. Whether 5-HT dynamics at shorter time scales can be seen to delineate substates within these larger brain states remains an open question. Here, we performed simultaneous recordings of extracellular 5-HT using a recently developed G-Protein-Coupled Receptor-Activation-Based 5-HT sensor (GRAB5-HT3.0) and local field potential in the hippocampal CA1 of mice, which revealed the presence of prominent ultraslow (<0.05 Hz) 5-HT oscillations both during NREM and WAKE states. Interestingly, the phase of these ultraslow 5-HT oscillations was found to distinguish substates both within and across l","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-27T17:07:17.872Z","creation":"2025-08-28T03:09:16.502Z"},"accession":"S-EPMC12252544","cross_references":{"pubmed":["40643572"],"doi":["10.7554/eLife.101105"]}}