{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["101(8)"],"submitter":["de Ram C"],"pubmed_abstract":["Mucin glycan degradation and utilization by microbes colonizing the human intestine is an essential host-microbe interaction. In this study, degradation and utilization of porcine gastric mucin glycans by Akkermansia muciniphila, Ruminococcus torques, Bacteroides thetaiotaomicron, co-cultures, and a synthetic bacterial community were investigated over time. Liquid chromatography-tandem mass spectrometry O-glycan patterns revealed that all three monocultures removed sialic acid residues. Furthermore, R. torques first targeted fucosylated O-glycans, while A. muciniphila and B. thetaiotaomicron equally favoured fucosylated and non-fucosylated O-glycans. A. muciniphila, R. torques, and B. thetaiotaomicron favoured degradation of first core 2 O-glycan structures relative to core 1 O-glycan stru"],"journal":["FEMS microbiology ecology"],"pagination":["fiaf066"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12258148"],"repository":["biostudies-literature"],"pubmed_title":["Distinct in vitro utilization and degradation of porcine gastric mucin glycans by human intestinal bacteria."],"pmcid":["PMC12258148"],"pubmed_authors":["O Pandeirada C","Belzer C","de Ram C","Hooiveld GJEJ","Schols HA","Vincken JP","Berkhout MD"],"additional_accession":[]},"is_claimable":false,"name":"Distinct in vitro utilization and degradation of porcine gastric mucin glycans by human intestinal bacteria.","description":"Mucin glycan degradation and utilization by microbes colonizing the human intestine is an essential host-microbe interaction. In this study, degradation and utilization of porcine gastric mucin glycans by Akkermansia muciniphila, Ruminococcus torques, Bacteroides thetaiotaomicron, co-cultures, and a synthetic bacterial community were investigated over time. Liquid chromatography-tandem mass spectrometry O-glycan patterns revealed that all three monocultures removed sialic acid residues. Furthermore, R. torques first targeted fucosylated O-glycans, while A. muciniphila and B. thetaiotaomicron equally favoured fucosylated and non-fucosylated O-glycans. A. muciniphila, R. torques, and B. thetaiotaomicron favoured degradation of first core 2 O-glycan structures relative to core 1 O-glycan stru","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-29T17:14:02.329Z","creation":"2026-04-08T05:24:51.915Z"},"accession":"S-EPMC12258148","cross_references":{"pubmed":["40581599"],"doi":["10.1093/femsec/fiaf066"]}}