{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(16)"],"submitter":["Dave R"],"pubmed_abstract":["This study expands the platform for amyloidogenic building blocks, such as nucleobases, and their self-assembly. Here, we examine the self-assembly profile of nucleobases such as guanine, cytosine, and thymine and determine that these nucleobases, while aged, produce small globules which gradually transform into fibrillar assemblies. Notably, the amyloid-like fibrillation in adenine and uracil has already been reported; hence, it was imperative to understand the amyloidogenic propensity in these unexplored nucleobases. The aggregates formed by guanine, cytosine, and thymine interestingly reveal a distinctive spectrum characteristic of amyloidogenic proteins after binding to the amyloid-specific dye Thioflavin T (ThT). The MTT assay in human retinal pigment epithelial RPE-1 cell lines revea"],"journal":["Nanoscale advances"],"pagination":["5093-5103"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12258404"],"repository":["biostudies-literature"],"pubmed_title":["Nucleobase self-assembly: aggregation, morphological characterization, and toxicity analysis."],"pmcid":["PMC12258404"],"pubmed_authors":["Verma S","Jaiswal A","Nazir A","Naseer A","Gour N","Dave R","Singh A","Bhatia D","Patel M"],"additional_accession":[]},"is_claimable":false,"name":"Nucleobase self-assembly: aggregation, morphological characterization, and toxicity analysis.","description":"This study expands the platform for amyloidogenic building blocks, such as nucleobases, and their self-assembly. Here, we examine the self-assembly profile of nucleobases such as guanine, cytosine, and thymine and determine that these nucleobases, while aged, produce small globules which gradually transform into fibrillar assemblies. Notably, the amyloid-like fibrillation in adenine and uracil has already been reported; hence, it was imperative to understand the amyloidogenic propensity in these unexplored nucleobases. The aggregates formed by guanine, cytosine, and thymine interestingly reveal a distinctive spectrum characteristic of amyloidogenic proteins after binding to the amyloid-specific dye Thioflavin T (ThT). The MTT assay in human retinal pigment epithelial RPE-1 cell lines revea","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-03-31T11:48:54.044Z","creation":"2025-09-01T03:05:54.375Z"},"accession":"S-EPMC12258404","cross_references":{"pubmed":["40666605"],"doi":["10.1039/d5na00259a"]}}