{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Li L"],"funding":["National Cancer Institute grant","NCI NIH HHS"],"pubmed_abstract":["<h4>Background</h4>Respiratory Syncytial Virus (RSV) causes significant respiratory infections, particularly in young children and elderly adults. Genetic variations in the fusion (F) protein can reduce the efficacy of vaccination and monoclonal antibody treatments, emphasizing the need for genomic surveillance of this virus.<h4>Motivation</h4>Current pipelines for RSV genome assembly focus on sequence reconstruction but often lack features for detecting genotypes, clinically relevant mutations, or presenting results in formats that are suitable for clinical researchers.<h4>Results</h4>We introduce RSVrecon, an advanced bioinformatics pipeline for comprehensive RSV genome assembly and phylogenetic analysis. RSVrecon processes raw FASTQ files into annotated variant reports and delivers resu"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.06.03.657184"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12258908"],"repository":["biostudies-literature"],"pubmed_title":["Bridging Genomics and Clinical Medicine: RSVrecon Enhances RSV Surveillance with Automated Genotyping and Clinically-important Mutation Reporting."],"pmcid":["PMC12258908"],"funding_grant_id":["P30 CA021765"],"pubmed_authors":["Yi H","Hijano DR","Brazelton JN","Hayden RT","Wu G","Li L","Webby RJ"],"additional_accession":[]},"is_claimable":false,"name":"Bridging Genomics and Clinical Medicine: RSVrecon Enhances RSV Surveillance with Automated Genotyping and Clinically-important Mutation Reporting.","description":"<h4>Background</h4>Respiratory Syncytial Virus (RSV) causes significant respiratory infections, particularly in young children and elderly adults. Genetic variations in the fusion (F) protein can reduce the efficacy of vaccination and monoclonal antibody treatments, emphasizing the need for genomic surveillance of this virus.<h4>Motivation</h4>Current pipelines for RSV genome assembly focus on sequence reconstruction but often lack features for detecting genotypes, clinically relevant mutations, or presenting results in formats that are suitable for clinical researchers.<h4>Results</h4>We introduce RSVrecon, an advanced bioinformatics pipeline for comprehensive RSV genome assembly and phylogenetic analysis. RSVrecon processes raw FASTQ files into annotated variant reports and delivers resu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-04-07T14:21:26.562Z","creation":"2026-04-07T14:01:27.16Z"},"accession":"S-EPMC12258908","cross_references":{"pubmed":["40661544"],"doi":["10.1101/2025.06.03.657184"]}}