{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Patel CJ"],"funding":["NIDDK NIH HHS","NIEHS NIH HHS"],"pubmed_abstract":["Non-genetic exposures-including nutrients, lifestyle factors, consumables, and pollutants-substantially contribute to phenotypic variation. Most studies assess only a few exposures or phenotypes, yielding fragmented exposome-phenome relationships. Systematic approaches are needed to quantify how the exposome-the totality of environmental exposures-relates broadly to clinically relevant phenotypes. We developed a resource benchmarking the exposome's role using data from the National Health and Nutrition Examination Survey (NHANES), cataloging 619 exposures and 278 phenotypes, and systematically testing associations (Phenotype-exposure-wide association study [P-ExWAS]). Among ~119k associations, 5% (n=5,661) were Bonferroni significant, and 40% replicated across independent population sample"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2025.06.05.25329055"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12259201"],"repository":["biostudies-literature"],"pubmed_title":["The architecture of exposome-phenome associations."],"pmcid":["PMC12259201"],"funding_grant_id":["U24 ES036819","R01 ES032470","R01 DK137993"],"pubmed_authors":["Patel CJ","Ioannidis JP","Manrai AK"],"additional_accession":[]},"is_claimable":false,"name":"The architecture of exposome-phenome associations.","description":"Non-genetic exposures-including nutrients, lifestyle factors, consumables, and pollutants-substantially contribute to phenotypic variation. Most studies assess only a few exposures or phenotypes, yielding fragmented exposome-phenome relationships. Systematic approaches are needed to quantify how the exposome-the totality of environmental exposures-relates broadly to clinically relevant phenotypes. We developed a resource benchmarking the exposome's role using data from the National Health and Nutrition Examination Survey (NHANES), cataloging 619 exposures and 278 phenotypes, and systematically testing associations (Phenotype-exposure-wide association study [P-ExWAS]). Among ~119k associations, 5% (n=5,661) were Bonferroni significant, and 40% replicated across independent population sample","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2025-08-27T03:11:21.269Z","creation":"2025-08-27T03:11:21.269Z"},"accession":"S-EPMC12259201","cross_references":{"pubmed":["40661264"],"doi":["10.1101/2025.06.05.25329055"]}}