{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["75(5)"],"submitter":["Zhu M"],"pubmed_abstract":["<h4>Aim</h4>The interaction between dental pulp stem cells (DPSCs) and vascular endothelial cells (ECs) is crucial to the speedy establishment of functional blood circulation within the transplanted pulp tissue. It is a complex process involving direct cell contact and paracrine signalling. The transmembrane domains of α1-Na<sup>+</sup>/K<sup>+</sup>-ATPase (ATP1A1) have been shown to influence tumour angiogenesis. Its role in regulating DPSCs/ECs interaction in vascular formation remains unknown. This study aimed to explore ATP1A1 on DPSCs/ECs communication, vascular network formation, and underlying mechanisms.<h4>Methods</h4>The formation of vessel structures within different culture systems was examined. The expression of pericyte-like markers and Na<sup>+</sup>/K<sup>+</sup>-ATPase-re"],"journal":["International dental journal"],"pagination":["100870"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12260422"],"repository":["biostudies-literature"],"pubmed_title":["ATP1A1-Driven Intercellular Contact Between Dental Pulp Stem Cell and Endothelial Cell Enhances Vasculogenic Activity."],"pmcid":["PMC12260422"],"pubmed_authors":["Zhu M","Wu B","Jiang S","Zhang C","Zou T"],"additional_accession":[]},"is_claimable":false,"name":"ATP1A1-Driven Intercellular Contact Between Dental Pulp Stem Cell and Endothelial Cell Enhances Vasculogenic Activity.","description":"<h4>Aim</h4>The interaction between dental pulp stem cells (DPSCs) and vascular endothelial cells (ECs) is crucial to the speedy establishment of functional blood circulation within the transplanted pulp tissue. It is a complex process involving direct cell contact and paracrine signalling. The transmembrane domains of α1-Na<sup>+</sup>/K<sup>+</sup>-ATPase (ATP1A1) have been shown to influence tumour angiogenesis. Its role in regulating DPSCs/ECs interaction in vascular formation remains unknown. This study aimed to explore ATP1A1 on DPSCs/ECs communication, vascular network formation, and underlying mechanisms.<h4>Methods</h4>The formation of vessel structures within different culture systems was examined. The expression of pericyte-like markers and Na<sup>+</sup>/K<sup>+</sup>-ATPase-re","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-31T10:27:38.204Z","creation":"2025-08-23T03:09:16.24Z"},"accession":"S-EPMC12260422","cross_references":{"pubmed":["40628202"],"doi":["10.1016/j.identj.2025.100870"]}}