{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Azlan A"],"funding":["National Institute of Allergy and Infectious Diseases","Johns Hopkins University Catalyst Award","NIAID NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["RP103828"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12263153"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["During oogenesis, self-renewal and differentiation of germline stem cells (GSCs) must be tightly regulated. The <i>Drosophila</i> female germline serves as an excellent model for studying these regulatory mechanisms. Here, we report that a previously uncharacterized gene <i>CG14545</i>, which we named <i>sakura</i>, is essential for oogenesis and female fertility in <i>Drosophila</i>. Sakura is predominantly expressed in the ovaries, particularly in the germline cells, including GSCs. sakura null mutant female flies display rudimentary ovaries with germline-less and tumorous phenotypes, fail to produce eggs, and are completely sterile. The germline-specific depletion of sakura impairs Dpp/BMP signaling, leading to aberrant <i>bag-of-marbles</i> (<i>bam</i>) expression, resulting in faulty "],"journal":["eLife"],"pubmed_title":["Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis."],"pmcid":["PMC12263153"],"funding_grant_id":["R03AI178064","R03 AI178064","R35GM145352","R35 GM145352"],"pubmed_authors":["Azlan A","Zhu L","Fukunaga R"],"additional_accession":[]},"is_claimable":false,"name":"Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis.","description":"During oogenesis, self-renewal and differentiation of germline stem cells (GSCs) must be tightly regulated. The <i>Drosophila</i> female germline serves as an excellent model for studying these regulatory mechanisms. Here, we report that a previously uncharacterized gene <i>CG14545</i>, which we named <i>sakura</i>, is essential for oogenesis and female fertility in <i>Drosophila</i>. Sakura is predominantly expressed in the ovaries, particularly in the germline cells, including GSCs. sakura null mutant female flies display rudimentary ovaries with germline-less and tumorous phenotypes, fail to produce eggs, and are completely sterile. The germline-specific depletion of sakura impairs Dpp/BMP signaling, leading to aberrant <i>bag-of-marbles</i> (<i>bam</i>) expression, resulting in faulty ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-31T10:22:22.441Z","creation":"2025-08-23T03:09:14.187Z"},"accession":"S-EPMC12263153","cross_references":{"pubmed":["40663062"],"doi":["10.7554/eLife.103828"]}}