biostudies-literatureZhu YMilitary Clinical Key Specialty - Emergency Intensive Care Medicine DepartmentNaval Medical University Youth start-up FundIndustry-Academic Cooperation Collaborative Education Project of the Ministry of Education634https://www.ebi.ac.uk/biostudies/studies/S-EPMC12265141biostudies-literatureUnknown30(1)<h4>Background</h4>Pressure ulcer is a significant issue that cannot be overlooked in septic patients. This study aims to explore the impact of pressure ulcers on the 28 day mortality rate of septic patients.<h4>Methods</h4>The data for this study were obtained from the MIMIC-IV v3.0 database. Univariate and multivariate analysis methods were employed to conduct an in-depth exploration of the 28 day mortality rate of septic patients. Kaplan-Meier survival curves were plotted to verify the influence of pressure ulcer on the 28 day mortality rate of septic patients. In addition, subgroup analysis was carried out to reveal the relationship between pressure ulcer and other confounding factors.<h4>Results</h4>Among the 20,280 patients included in the MIMIC-IV cohort, 880 had pressure ulcers. BoEuropean journal of medical researchAssociation between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV database.PMC12265141September 2024 batchJDLCZDZK-LWF2023QN088Lei JYZou JZhu YCao FLiu XFLi WFfalseAssociation between pressure ulcer and 28-day mortality in septic patients: a retrospective study based on the MIMIC-IV database.<h4>Background</h4>Pressure ulcer is a significant issue that cannot be overlooked in septic patients. This study aims to explore the impact of pressure ulcers on the 28 day mortality rate of septic patients.<h4>Methods</h4>The data for this study were obtained from the MIMIC-IV v3.0 database. Univariate and multivariate analysis methods were employed to conduct an in-depth exploration of the 28 day mortality rate of septic patients. Kaplan-Meier survival curves were plotted to verify the influence of pressure ulcer on the 28 day mortality rate of septic patients. In addition, subgroup analysis was carried out to reveal the relationship between pressure ulcer and other confounding factors.<h4>Results</h4>Among the 20,280 patients included in the MIMIC-IV cohort, 880 had pressure ulcers. Bo2025-01-01T00:00:00Z2025 Jul2026-07-15T10:56:24.416Z2025-08-15T03:06:21.757ZS-EPMC122651414066544710.1186/s40001-025-02909-5