{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Long XE"],"funding":["Science & Technology Projects in Guangzhou","Jiangmen Basic and Applied Basic Research Project","Department of Education of Guangdong Province","Guangdong Basic and Applied Basic Research Foundation","National Natural Science Foundation of China"],"pagination":["213"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12265328"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["Analogues of chlamydocin derivatives consistently demonstrate multifaceted bioactivities, particularly through HDAC inhibition mechanisms, oncolytic efficacy, and neuronal preservation capacities. These activities primarily originate from their unique cyclic tetrapeptide scaffold and functional groups within the side chains that enable specific interactions with biomacromolecules. We herein report the total syntheses of three naturally occurring chlamydocin analogues-koshidacin B, TAN-1746, and Ac-TAN-1746. The synthetic strategy employed a modular approach that involved modifying a common intermediate via late-stage olefin cross-metathesis to install the requisite side-chain fragments. This versatile approach enabled an efficient and divergent total synthesis of the target compounds, comp"],"journal":["BMC chemistry"],"pubmed_title":["Total synthesis and biological evaluation of Koshidacin B, TAN-1746, and Ac-TAN-1746."],"pmcid":["PMC12265328"],"funding_grant_id":["2025A04J3399","2021ZDJS097","2022A1515110592, 2023A1515012715, and 2025A1515011064","202301003003140","82473801, 82104019"],"pubmed_authors":["Long XE","Liu J","He Y","Cao X","Yan JL","Xing H","Ma Y","Cheng MJ","Liu C","Nan H","Meng X"],"additional_accession":[]},"is_claimable":false,"name":"Total synthesis and biological evaluation of Koshidacin B, TAN-1746, and Ac-TAN-1746.","description":"Analogues of chlamydocin derivatives consistently demonstrate multifaceted bioactivities, particularly through HDAC inhibition mechanisms, oncolytic efficacy, and neuronal preservation capacities. These activities primarily originate from their unique cyclic tetrapeptide scaffold and functional groups within the side chains that enable specific interactions with biomacromolecules. We herein report the total syntheses of three naturally occurring chlamydocin analogues-koshidacin B, TAN-1746, and Ac-TAN-1746. The synthetic strategy employed a modular approach that involved modifying a common intermediate via late-stage olefin cross-metathesis to install the requisite side-chain fragments. This versatile approach enabled an efficient and divergent total synthesis of the target compounds, comp","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-16T08:08:25.948Z","creation":"2025-08-16T03:05:50.946Z"},"accession":"S-EPMC12265328","cross_references":{"pubmed":["40671014"],"doi":["10.1186/s13065-025-01581-4"]}}