{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Tsotras M"],"funding":["NICHD NIH HHS","NIA NIH HHS","NIMH NIH HHS","NIH HHS"],"pubmed_abstract":["Large-scale brain networks are vulnerable to change with aging and become dysregulated. How these networks are altered at the cellular level remains unclear owing to challenges of bridging data across scales. Here, we integrate <i>in vivo</i> cortical similarity networks with whole brain spatial transcriptomics to characterize the aging brain in a lifespan cohort of macaques (N=64, ages 1-26 years). Deep-layer excitatory neurons and oligodendrocytes emerged as dominant correlates of cortical similarity, linking infragranular cell type composition to macroscopic network structure. Age-related declines in network strength were most pronounced in transmodal networks, including default mode and limbic, and aligned with regions enriched in inhibitory and glial cell types. Parvalbumin-enriched c"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.07.08.663725"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12265686"],"repository":["biostudies-literature"],"pubmed_title":["Cellular basis for cortical network aging in primates."],"pmcid":["PMC12265686"],"funding_grant_id":["K99 MH101338","R01 HD096436","RF1 AG078340","P51 OD011107","R21 AG087904","R21 AG083539"],"pubmed_authors":["Raven EP","Veraart J","Evans AC","Tsotras M","Charbonneau JA","Bliss-Moreau E","Lepage C","Bennett JL"],"additional_accession":[]},"is_claimable":false,"name":"Cellular basis for cortical network aging in primates.","description":"Large-scale brain networks are vulnerable to change with aging and become dysregulated. How these networks are altered at the cellular level remains unclear owing to challenges of bridging data across scales. Here, we integrate <i>in vivo</i> cortical similarity networks with whole brain spatial transcriptomics to characterize the aging brain in a lifespan cohort of macaques (N=64, ages 1-26 years). Deep-layer excitatory neurons and oligodendrocytes emerged as dominant correlates of cortical similarity, linking infragranular cell type composition to macroscopic network structure. Age-related declines in network strength were most pronounced in transmodal networks, including default mode and limbic, and aligned with regions enriched in inhibitory and glial cell types. Parvalbumin-enriched c","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-04-08T18:33:43.806Z","creation":"2026-04-08T09:53:10.546Z"},"accession":"S-EPMC12265686","cross_references":{"pubmed":["40672262"],"doi":["10.1101/2025.07.08.663725"]}}