{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Manoharan MS"],"funding":["Intramural NIH HHS","NCATS NIH HHS","NIDCR NIH HHS","NIA NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","United States Air Force (DoD)","U.S. Department of Veterans Affairs","NIH HHS","NIGMS NIH HHS","CSRD VA"],"pagination":["e70063"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12266754"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(7)"],"pubmed_abstract":["Human aging presents an evolutionary paradox: while aging rates remain constant, healthspan and lifespan vary widely. We address this conundrum via salutogenesis-the active production of health-through immune resilience (IR), the capacity to resist disease despite aging and inflammation. Analyzing ~17,500 individuals across lifespan stages and inflammatory challenges, we identified a core salutogenic mechanism: IR centered on TCF7, a conserved transcription factor maintaining T-cell stemness and regenerative potential. IR integrates innate and adaptive immunity to counter three aging and mortality drivers: chronic inflammation (inflammaging), immune aging, and cellular senescence. By mitigating these aging mechanisms, IR confers survival advantages: At age 40, individuals with poor IR face"],"journal":["Aging cell"],"pubmed_title":["The 15-Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging."],"pmcid":["PMC12266754"],"funding_grant_id":["T32DE014318","IP1 CX000875","R21GM147800","UM1 TR004538","HHSN268201500001C","IP1 CX000875-01A1","T32 DE014318","K23 AG066933","K23AG066933","COVID19-8100-01","R37 AI046326","1UM1TR004538","R37AI046326","R21 GM147800","ZIA AI001202","ZIA HG200374","ZIA HG200373","Z01 AI000825","ZIA HG200371","FA8650-17-2-6816","AAI20042-001","HHSN268201500001I"],"pubmed_authors":["Carrillo A","Grigsby S","Lester CS","Pascual-Guardia S","Louder A","Tovar EJ","Medlin L","Zhang N","Polk PB","Munro SB","Reichelderfer RL","Bolan-Reding SN","Sanchez-Reilly S","Ratcliffe TA","Dickerson J","Sanchez ME","Arellanes A","Grassmuck S","Rudd T","Escalante M","Stewart E","Walker M","Jewell P","Banfield AB","Okulicz JF","Hanson J","Sanders T","Ho TT","Nambiar A","Agnew J","Maldonado R","Farrar R","Colazo R","He W","Schmit D","Quitta RF","Winter CA","Varela CJ","Lawler AC","Lewis HV","Briggs H","Anzueto A","Harper N","Smith AM","Branum AP","Jabur A","Feldman D","Lee M","Escamilla V","Abdalla MI","Braddy S","Doanne J","Soni N","Dhami C","Renz EM","Gaitan AA","Ross J","Hinojosa C","DePaul SA","Danaher PJ","Venticinque SG","McElligott N","Adebayo Y","Levine SM","Nassery D","Garza MA","Foy JD","Preston KJ","Nicholson S","Veloso MC","Jo G","Goel M","Clark RA","Phillips RE","Moreno J","Barnett C","Benavides R","Johnson TB","Patterson M","Yabes JM","STVHCS Center for Personalized Medicine","Birdwell A","Adams SG","Bradford S","Flores D","Wang E","Barker J","DeLeon KS","Meunier JA","South Texas Veterans Health Care System (STVHCS) COVID‐19 Clinical team","O'Rorke J","Ramirez LJ","Oakman K","Marin-Corral J","Garza M","Murray C","Butler CR","Padgett C","Peters JI","Diaz NG","STVHCS COVID‐19 Vaccine team","Tam WS","Salehi M","Noronha M","Segal LN","Flynn J","Freeman M","Trinh HD","Pugh JA","Restrepo MI","Nathanson R","Villanueva M","STVHCS COVID‐19 Convalescent care team","Hopkins T","Jiva K","Rangel M","Garcia J","Goyal VK","Morneau K","Pandranki L","Hecht JM","Mang H","Martinez C","Mader M","Balmes M","Tyler AR","Escamilla C","Wallace A","Martinez Y","Melby P","Wickizer S","Karekatt S","Villegas L","Wallace M","Angel L","Haywood A","Mireles M","Andampour K","Zentner KH","Ahuja SK","Winter LA","Perez GL","Pomager MA","Bible V","Hussain AN","Schindler KC","Williamson A","Sehgal RT","Moreira AG","Cadena Zuluaga JA","Muetz J","Solorzano C","Villalpando JA","Perez R","Paleracio E","Manoharan MS","Tripathy D","Kadhume R","Vasquez A","Yunes A","Jimenez F","Gomez J","Proud KC","Harris B","Mata C","Ali S","Elbel S","Gilman S","Mainor C","Ford D","Robinson E","Anstead G","Trammell Velasquez SA","Lee GC","Dacus JJ","Galley S"],"additional_accession":[]},"is_claimable":false,"name":"The 15-Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging.","description":"Human aging presents an evolutionary paradox: while aging rates remain constant, healthspan and lifespan vary widely. We address this conundrum via salutogenesis-the active production of health-through immune resilience (IR), the capacity to resist disease despite aging and inflammation. Analyzing ~17,500 individuals across lifespan stages and inflammatory challenges, we identified a core salutogenic mechanism: IR centered on TCF7, a conserved transcription factor maintaining T-cell stemness and regenerative potential. IR integrates innate and adaptive immunity to counter three aging and mortality drivers: chronic inflammation (inflammaging), immune aging, and cellular senescence. By mitigating these aging mechanisms, IR confers survival advantages: At age 40, individuals with poor IR face","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-27T15:18:03.904Z","creation":"2025-08-23T03:08:54.331Z"},"accession":"S-EPMC12266754","cross_references":{"pubmed":["40264357"],"doi":["10.1111/acel.70063"]}}