{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Forester BR"],"funding":["Natural Sciences and Engineering Research Council of Canada","David L. Boren Fellowship","NICHD NIH HHS","NHGRI NIH HHS","University of Northern British Columbia","National Institutes of Health","NIGMS NIH HHS","NIH HHS","National Science Foundation"],"pagination":["e17651"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12267553"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(23)"],"pubmed_abstract":["Identifying populations at highest risk from climate change is a critical component of conservation efforts. However, vulnerability assessments are usually applied at the species level, even though intraspecific variation in exposure, sensitivity and adaptive capacity play a crucial role in determining vulnerability. Genomic data can inform intraspecific vulnerability by identifying signatures of local adaptation that reflect population-level variation in sensitivity and adaptive capacity. Here, we address the question of local adaptation to temperature and the genetic basis of thermal tolerance in two stream frogs (Ascaphus truei and A. montanus). Building on previous physiological and temperature data, we used whole-genome resequencing of tadpoles from four sites spanning temperature gra"],"journal":["Molecular ecology"],"pubmed_title":["Population Genomics Reveals Local Adaptation Related to Temperature Variation in Two Stream Frog Species: Implications for Vulnerability to Climate Warming."],"pmcid":["PMC12267553"],"funding_grant_id":["PGSD2-532408-2019","S10 OD010786","PGSD2‐532408‐2019","26896","T32HG000047","R01HD065705","T32 GM007127","DEB‐2221809","R01 HD065705","DEB-2221809","S10 OD018174","S10OD010786","R01 HD080708","DEB‐1838282","R01HD080708","R01GM086321","R01 GM086321","DEB-1838282","T32GM007127","S10OD018174","T32 HG000047"],"pubmed_authors":["Dunham JB","Shah AA","Murray BW","Crawford AJ","Landguth EL","Mudd AB","Rokhsar D","Cicchino AS","Bredeson JV","Anderson EC","Forester BR","Funk WC","Ghalambor CK"],"additional_accession":[]},"is_claimable":false,"name":"Population Genomics Reveals Local Adaptation Related to Temperature Variation in Two Stream Frog Species: Implications for Vulnerability to Climate Warming.","description":"Identifying populations at highest risk from climate change is a critical component of conservation efforts. However, vulnerability assessments are usually applied at the species level, even though intraspecific variation in exposure, sensitivity and adaptive capacity play a crucial role in determining vulnerability. Genomic data can inform intraspecific vulnerability by identifying signatures of local adaptation that reflect population-level variation in sensitivity and adaptive capacity. Here, we address the question of local adaptation to temperature and the genetic basis of thermal tolerance in two stream frogs (Ascaphus truei and A. montanus). Building on previous physiological and temperature data, we used whole-genome resequencing of tadpoles from four sites spanning temperature gra","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T17:28:31.372Z","creation":"2026-06-03T03:10:30.199Z"},"accession":"S-EPMC12267553","cross_references":{"pubmed":["39825598"],"doi":["10.1111/mec.17651"]}}